Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1131787..1132640 Replicon chromosome
Accession NZ_CP102541
Organism Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)


Gene name relE Uniprot ID D6ZUU6
Locus tag NUU11_RS05145 Protein ID WP_013140895.1
Coordinates 1132149..1132640 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag NUU11_RS05140 Protein ID WP_011068030.1
Coordinates 1131787..1132149 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU11_RS05135 (NUU11_05135) 1128942..1131641 + 2700 WP_212104897.1 aconitate hydratase AcnA -
NUU11_RS05140 (NUU11_05140) 1131787..1132149 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU11_RS05145 (NUU11_05145) 1132149..1132640 + 492 WP_013140895.1 PIN domain-containing protein Toxin
NUU11_RS05150 (NUU11_05150) 1132700..1134805 - 2106 WP_013140894.1 DUF262 domain-containing protein -
NUU11_RS05155 (NUU11_05155) 1134894..1135535 - 642 WP_077425506.1 GNAT family N-acetyltransferase -
NUU11_RS05160 (NUU11_05160) 1135576..1135716 - 141 Protein_1000 LuxR C-terminal-related transcriptional regulator -
NUU11_RS05165 (NUU11_05165) 1136000..1136902 + 903 WP_212104901.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18314.88 Da        Isoelectric Point: 4.5590

>T253821 WP_013140895.1 NZ_CP102541:1132149-1132640 [Bifidobacterium longum subsp. infantis]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRREFKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCKTPAEIVA
ALE

Download         Length: 492 bp

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT253821 WP_011068030.1 NZ_CP102541:1131787-1132149 [Bifidobacterium longum subsp. infantis]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A564VMG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References