Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 1045237..1045820 Replicon chromosome
Accession NZ_CP102541
Organism Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)


Gene name PumA Uniprot ID A0A1S2VZ23
Locus tag NUU11_RS04800 Protein ID WP_032745284.1
Coordinates 1045518..1045820 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID I3AVV5
Locus tag NUU11_RS04795 Protein ID WP_007057517.1
Coordinates 1045237..1045521 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU11_RS04775 (NUU11_04775) 1041743..1042825 + 1083 Protein_923 transposase -
NUU11_RS04780 (NUU11_04780) 1042923..1043831 + 909 WP_193641239.1 ABC transporter ATP-binding protein -
NUU11_RS04785 (NUU11_04785) 1043828..1044559 + 732 WP_032744305.1 ABC transporter permease -
NUU11_RS04790 (NUU11_04790) 1044577..1045128 - 552 Protein_926 IS30 family transposase -
NUU11_RS04795 (NUU11_04795) 1045237..1045521 - 285 WP_007057517.1 putative addiction module antidote protein Antitoxin
NUU11_RS04800 (NUU11_04800) 1045518..1045820 - 303 WP_032745284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUU11_RS04805 (NUU11_04805) 1045858..1046187 - 330 WP_257798116.1 DUF1922 domain-containing protein -
NUU11_RS04810 (NUU11_04810) 1046313..1046801 + 489 WP_032745281.1 D-aminoacyl-tRNA deacylase -
NUU11_RS04815 (NUU11_04815) 1046962..1050081 + 3120 WP_212104835.1 alpha-mannosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1038045..1048898 10853
- flank IS/Tn - - 1044577..1045032 455


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(9-92)

Antitoxin

Uncharacterized protein HI1420

(3-92)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11350.08 Da        Isoelectric Point: 10.4626

>T253820 WP_032745284.1 NZ_CP102541:c1045820-1045518 [Bifidobacterium longum subsp. infantis]
IKQSAEYRKWFKKLRDHKAKAAIQARLDACKLAGRPFGDIKPVGGPVSEMRFHTGAGYRVYFAMQGNVLMLLLAGGDKST
QQTDIRQAHDILNDYKEQRQ

Download         Length: 303 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10158.37 Da        Isoelectric Point: 4.3707

>AT253820 WP_007057517.1 NZ_CP102541:c1045521-1045237 [Bifidobacterium longum subsp. infantis]
MSTEFTDYDTSEYLENEQDIIAYLNAIAEYDDPALMQAALGNVAKARGMTQIAKDAGVGRESLYKSLSKDGNPSFQTIAK
VIHALGGRLTIQAA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2VZ23

Antitoxin

Source ID Structure
AlphaFold DB I3AVV5

References