Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 14946..15511 Replicon chromosome
Accession NZ_CP102541
Organism Bifidobacterium longum subsp. infantis strain BB-02

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NUU11_RS00055 Protein ID WP_234895543.1
Coordinates 14946..15161 (-) Length 72 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B7GSH1
Locus tag NUU11_RS00060 Protein ID WP_012576473.1
Coordinates 15233..15511 (-) Length 93 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU11_RS00035 (NUU11_00035) 10155..10721 + 567 WP_032743433.1 DUF3566 domain-containing protein -
NUU11_RS00040 (NUU11_00040) 11367..12788 + 1422 WP_071477783.1 ATP-binding protein -
NUU11_RS00045 (NUU11_00045) 12849..13073 - 225 WP_060620314.1 substrate-binding domain-containing protein -
NUU11_RS00050 (NUU11_00050) 13224..14570 - 1347 WP_193641811.1 NADP-specific glutamate dehydrogenase -
NUU11_RS00055 (NUU11_00055) 14946..15161 - 216 WP_234895543.1 type II toxin-antitoxin system YafQ family toxin Toxin
NUU11_RS00060 (NUU11_00060) 15233..15511 - 279 WP_012576473.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU11_RS00065 (NUU11_00065) 15985..16212 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
NUU11_RS00070 (NUU11_00070) 16315..16959 + 645 WP_212104116.1 hypothetical protein -
NUU11_RS00075 (NUU11_00075) 17381..17935 - 555 WP_187324443.1 hypothetical protein -
NUU11_RS00090 (NUU11_00090) 19050..20312 - 1263 WP_212104118.1 metallophosphoesterase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-70)

Antitoxin

(6-70)


Sequences


Toxin        


Download         Length: 72 a.a.        Molecular weight: 7872.07 Da        Isoelectric Point: 6.0467

>T253819 WP_234895543.1 NZ_CP102541:c15161-14946 [Bifidobacterium longum subsp. infantis]
MDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVLVLTLTRTGTHSDLFGK

Download         Length: 216 bp


Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10202.63 Da        Isoelectric Point: 6.3216

>AT253819 WP_012576473.1 NZ_CP102541:c15511-15233 [Bifidobacterium longum subsp. infantis]
MSGTTTTVNVRMNAELKKQAEELFGELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0A8MHE5

References