Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RelB(antitoxin)
Location 1043721..1044360 Replicon chromosome
Accession NZ_CP102536
Organism Bifidobacterium breve strain BIF195

Toxin (Protein)


Gene name mazF Uniprot ID D4BP71
Locus tag NUU00_RS04435 Protein ID WP_003829234.1
Coordinates 1043721..1044077 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NUU00_RS04440 Protein ID WP_003829235.1
Coordinates 1044064..1044360 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU00_RS04405 (NUU00_04405) 1038908..1039819 + 912 WP_003829224.1 ABC transporter ATP-binding protein -
NUU00_RS04410 (NUU00_04410) 1040016..1040642 + 627 WP_003829226.1 30S ribosomal protein S4 -
NUU00_RS04415 (NUU00_04415) 1040979..1041761 - 783 WP_015438747.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
NUU00_RS04420 (NUU00_04420) 1041907..1042392 - 486 WP_003829229.1 cytidine deaminase -
NUU00_RS04425 (NUU00_04425) 1042481..1042837 + 357 WP_003829232.1 SdpI family protein -
NUU00_RS04430 (NUU00_04430) 1042942..1043544 + 603 WP_003829233.1 transglutaminase family protein -
NUU00_RS04435 (NUU00_04435) 1043721..1044077 - 357 WP_003829234.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NUU00_RS04440 (NUU00_04440) 1044064..1044360 - 297 WP_003829235.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUU00_RS04445 (NUU00_04445) 1044508..1044672 - 165 Protein_862 IS30 family transposase -
NUU00_RS04450 (NUU00_04450) 1044772..1045446 + 675 WP_025262941.1 histidine phosphatase family protein -
NUU00_RS04455 (NUU00_04455) 1045529..1045933 + 405 WP_003829238.1 DUF948 domain-containing protein -
NUU00_RS04460 (NUU00_04460) 1045933..1046169 + 237 WP_003829239.1 hypothetical protein -
NUU00_RS04465 (NUU00_04465) 1046265..1048943 + 2679 WP_003829240.1 alanine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-110)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(12-54)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13316.23 Da        Isoelectric Point: 7.9984

>T253817 WP_003829234.1 NZ_CP102536:c1044077-1043721 [Bifidobacterium breve]
MMKTDPHQFEIWWVPFTFPDKPGKAKNRPSVILQWDDGTRIALVTKVTGNTWRDEPGYVVLRDWQDAGLSKPSAVRCSQL
LRLPSSLFLDDGPTGRLSAYDAGRVTWAINELYPGLLA

Download         Length: 357 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10997.50 Da        Isoelectric Point: 4.2896

>AT253817 WP_003829235.1 NZ_CP102536:c1044360-1044064 [Bifidobacterium breve]
MMAIKEKTTISLDAQTKRDGIAILDAMGLNLSTFAEMSLRQLVRDGRLPFTPSVRPSFEKDNEGYPLFKANMDDPRIVTP
QIRDGAVILPEGWDDDED

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0L7B6G7

Antitoxin

Source ID Structure

References