Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1141337..1141830 Replicon chromosome
Accession NZ_CP102534
Organism Enterococcus faecium strain ENCfa-68

Toxin (Protein)


Gene name relE Uniprot ID A0A829A9S0
Locus tag NUU03_RS05565 Protein ID WP_002342567.1
Coordinates 1141564..1141830 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A829AAJ0
Locus tag NUU03_RS05560 Protein ID WP_002329324.1
Coordinates 1141337..1141567 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU03_RS05535 (NUU03_05510) 1136808..1137140 + 333 WP_002342563.1 hypothetical protein -
NUU03_RS05540 (NUU03_05515) 1137209..1138371 + 1163 WP_087628202.1 IS3 family transposase -
NUU03_RS05545 (NUU03_05520) 1138792..1139420 - 629 Protein_1098 glutamine amidotransferase -
NUU03_RS05550 (NUU03_05525) 1140208..1140513 + 306 WP_002342565.1 hypothetical protein -
NUU03_RS05555 (NUU03_05530) 1140568..1140861 + 294 WP_016853226.1 hypothetical protein -
NUU03_RS05560 (NUU03_05535) 1141337..1141567 + 231 WP_002329324.1 DUF6290 family protein Antitoxin
NUU03_RS05565 (NUU03_05540) 1141564..1141830 + 267 WP_002342567.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUU03_RS05570 (NUU03_05545) 1142082..1142309 + 228 WP_002329322.1 hypothetical protein -
NUU03_RS05575 (NUU03_05550) 1142325..1143491 + 1167 WP_002329321.1 radical SAM family heme chaperone HemW -
NUU03_RS05580 (NUU03_05555) 1143724..1144767 + 1044 WP_073441383.1 heat-inducible transcriptional repressor HrcA -
NUU03_RS05585 (NUU03_05560) 1144861..1145424 + 564 WP_002292135.1 nucleotide exchange factor GrpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10651.28 Da        Isoelectric Point: 10.1925

>T253815 WP_002342567.1 NZ_CP102534:1141564-1141830 [Enterococcus faecium]
MTYRLEFTPEIQKQLRKMDKHQATLIVRWLYQHIDGIDDPRKFGKGFTANRSGQWRYRIGKYRVLVEIEDDQMVVIAIQV
GHRRNIYD

Download         Length: 267 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8863.97 Da        Isoelectric Point: 4.1938

>AT253815 WP_002329324.1 NZ_CP102534:1141337-1141567 [Enterococcus faecium]
MAMITVRVSDAEKEWLSYMAEFYGITLSELLKTYSMEQLEDEYDRQTAEIAHKHWVESGKTTVSMEEILHEFGGLE

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829A9S0

Antitoxin

Source ID Structure
AlphaFold DB A0A829AAJ0

References