Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 2679130..2679781 Replicon chromosome
Accession NZ_CP102530
Organism Lacticaseibacillus paracasei subsp. paracasei strain 01

Toxin (Protein)


Gene name pemK Uniprot ID K6S8L5
Locus tag NUU02_RS13205 Protein ID WP_003567661.1
Coordinates 2679130..2679513 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID K0NCT7
Locus tag NUU02_RS13210 Protein ID WP_014566665.1
Coordinates 2679533..2679781 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU02_RS13200 (NUU02_13200) 2678435..2678956 - 522 WP_012492007.1 QueT transporter family protein -
NUU02_RS13205 (NUU02_13205) 2679130..2679513 - 384 WP_003567661.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NUU02_RS13210 (NUU02_13210) 2679533..2679781 - 249 WP_014566665.1 antitoxin Antitoxin
NUU02_RS13215 (NUU02_13215) 2679849..2680985 - 1137 WP_003576478.1 alanine racemase -
NUU02_RS13220 (NUU02_13220) 2680972..2681346 - 375 WP_003567669.1 holo-ACP synthase -
NUU02_RS13225 (NUU02_13225) 2681516..2683024 - 1509 WP_003567670.1 DEAD/DEAH box helicase -
NUU02_RS13230 (NUU02_13230) 2683324..2684712 - 1389 WP_003567677.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13773.03 Da        Isoelectric Point: 10.9764

>T253812 WP_003567661.1 NZ_CP102530:c2679513-2679130 [Lacticaseibacillus paracasei subsp. paracasei]
MDVSVKRGDVFFADLSPVVGSEQGGNRPVLIIQNNVGNHYSPTVIVAAITSKIQKPKMPTHVGLRAKQDGVERNSVILLE
QIRTIDKQRLQARVTALSSTKMAAVDRALAISVGLVSLPKPKTYNKN

Download         Length: 384 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8966.14 Da        Isoelectric Point: 4.4610

>AT253812 WP_014566665.1 NZ_CP102530:c2679781-2679533 [Lacticaseibacillus paracasei subsp. paracasei]
MKKQTSVAVTFDDAIKARLDAYCELNDIDAQAVITEAVATFLKSQAPEINQLISGYVAMGQINTEISHAFSACESEVYAH
IR

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K6S8L5

Antitoxin

Source ID Structure
AlphaFold DB K0NCT7

References