253810

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higB-toxA/Tad-HTH_37
Location 462502..463130 Replicon chromosome
Accession NZ_CP102530
Organism Lacticaseibacillus paracasei subsp. paracasei strain 01

Toxin (Protein)


Gene name higB Uniprot ID A0A806L3G4
Locus tag NUU02_RS02275 Protein ID WP_012490993.1
Coordinates 462762..463130 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag NUU02_RS02270 Protein ID WP_003583264.1
Coordinates 462502..462762 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUU02_RS02245 (NUU02_02245) 458393..459136 + 744 WP_012490990.1 SDR family oxidoreductase -
NUU02_RS02250 (NUU02_02250) 459249..459875 + 627 WP_003577713.1 flavodoxin -
NUU02_RS02255 (NUU02_02255) 460126..460629 + 504 WP_012490991.1 TetR/AcrR family transcriptional regulator -
NUU02_RS02260 (NUU02_02260) 460634..461695 + 1062 WP_003563374.1 ABC transporter permease -
NUU02_RS02265 (NUU02_02265) 461700..462389 + 690 WP_012490992.1 ABC transporter ATP-binding protein -
NUU02_RS02270 (NUU02_02270) 462502..462762 - 261 WP_003583264.1 helix-turn-helix transcriptional regulator Antitoxin
NUU02_RS02275 (NUU02_02275) 462762..463130 - 369 WP_012490993.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUU02_RS02280 (NUU02_02280) 463421..464791 - 1371 WP_012490994.1 FAD-dependent oxidoreductase -
NUU02_RS02285 (NUU02_02285) 465155..465973 - 819 WP_012490995.1 Cof-type HAD-IIB family hydrolase -
NUU02_RS02290 (NUU02_02290) 466289..466558 - 270 WP_012490996.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
NUU02_RS02295 (NUU02_02295) 466799..467806 + 1008 WP_003563383.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(34-112)

Antitoxin

Cro/C1-type helix-turn-helix domain

(28-79)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 14970.02 Da        Isoelectric Point: 8.3986

>T253810 WP_012490993.1 NZ_CP102530:c463130-462762 [Lacticaseibacillus paracasei subsp. paracasei]
MYKIDFYEDRDGYSEIEDFLDQLRHSHQKNNVSLLNKITKELYMLQNLGPRLREPHAKFLKGYAYPIMELRPMQERIFYA
AWQKDHFVLLHHYTKKTNKTDHREILRAQSNLEDWLSRKEEN

Download         Length: 369 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9828.45 Da        Isoelectric Point: 10.2439

>AT253810 WP_003583264.1 NZ_CP102530:c462762-462502 [Lacticaseibacillus paracasei subsp. paracasei]
MTTWEDFSQKLKKDNPEKLAIIKTLADLESERIKQGISQKDFAEKIGMKQPQLAKIERLDSLPTLATLNRYARGLGKEIR
LSIVTQ

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806L3G4

Antitoxin

Source ID Structure

References