Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3590258..3590892 Replicon chromosome
Accession NZ_CP102514
Organism Streptomyces yangpuensis strain CM253

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NRK68_RS16325 Protein ID WP_183066303.1
Coordinates 3590470..3590892 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NRK68_RS16320 Protein ID WP_183066302.1
Coordinates 3590258..3590473 (+) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NRK68_RS16300 (NRK68_16300) 3585877..3587130 - 1254 WP_183066300.1 phosphoribosylamine--glycine ligase -
NRK68_RS16305 (NRK68_16305) 3587192..3589447 - 2256 WP_257856089.1 DNA polymerase III subunit gamma and tau -
NRK68_RS16320 (NRK68_16320) 3590258..3590473 + 216 WP_183066302.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NRK68_RS16325 (NRK68_16325) 3590470..3590892 + 423 WP_183066303.1 PIN domain nuclease Toxin
NRK68_RS16330 (NRK68_16330) 3590972..3591754 - 783 WP_257856090.1 hypothetical protein -
NRK68_RS16335 (NRK68_16335) 3591877..3592689 - 813 WP_257856091.1 VOC family protein -
NRK68_RS16340 (NRK68_16340) 3592793..3593419 + 627 WP_257857868.1 HhH-GPD-type base excision DNA repair protein -
NRK68_RS16345 (NRK68_16345) 3593512..3593985 + 474 WP_183066307.1 cupin domain-containing protein -
NRK68_RS16350 (NRK68_16350) 3593934..3594866 - 933 WP_183066308.1 glucose-6-phosphate dehydrogenase assembly protein OpcA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-49)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15569.45 Da        Isoelectric Point: 5.1708

>T253807 WP_183066303.1 NZ_CP102514:3590470-3590892 [Streptomyces yangpuensis]
VNAAQFLIDTSALARFMRRDAEQYGWDQAAAAGLIATCPITELEFFYSARSTADRARGIEDMRLIFGWVSVDDRAYDRAW
QVQDALTRQGKHRSAGAVDLVVAATAELQGLTLLHRDHDFECIAAVTGQPLQWYGPEHGK

Download         Length: 423 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 8078.16 Da        Isoelectric Point: 8.6591

>AT253807 WP_183066302.1 NZ_CP102514:3590258-3590473 [Streptomyces yangpuensis]
MSRTVIDLDDELVADVAKALGTSTKKETVNTALREVLENRRRALALTRLRAAADEGAFDLELFENKRNYRR

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References