Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4127914..4128478 Replicon chromosome
Accession NZ_CP102513
Organism Streptomyces sp. DSM 40750

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag JIX55_RS18460 Protein ID WP_257564407.1
Coordinates 4127914..4128261 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag JIX55_RS18465 Protein ID WP_257569375.1
Coordinates 4128248..4128478 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIX55_RS18445 (JIX55_18445) 4124580..4125785 - 1206 WP_257564405.1 hypothetical protein -
JIX55_RS18450 (JIX55_18450) 4125787..4126263 - 477 WP_257569374.1 sigma-70 family RNA polymerase sigma factor -
JIX55_RS18455 (JIX55_18455) 4126821..4127852 + 1032 WP_257564406.1 aspartate-semialdehyde dehydrogenase -
JIX55_RS18460 (JIX55_18460) 4127914..4128261 - 348 WP_257564407.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
JIX55_RS18465 (JIX55_18465) 4128248..4128478 - 231 WP_257569375.1 ribbon-helix-helix domain-containing protein Antitoxin
JIX55_RS18470 (JIX55_18470) 4128579..4131158 + 2580 WP_257564408.1 aminopeptidase N -
JIX55_RS18475 (JIX55_18475) 4131246..4132217 - 972 WP_257564409.1 EamA family transporter -
JIX55_RS18480 (JIX55_18480) 4132371..4132907 + 537 WP_257564410.1 MarR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-39)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12504.49 Da        Isoelectric Point: 10.3418

>T253806 WP_257564407.1 NZ_CP102513:c4128261-4127914 [Streptomyces sp. DSM 40750]
MKRGDIYLVDYEPARGSEASKARPAVIVSNDGANAAAARTGRGVITLVPLTTNTSRVYPFQVLLPAQECGLPKDSKVQCE
QVRALAPERLLRPIGSVPRQRMAEVDVALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8575.28 Da        Isoelectric Point: 3.8158

>AT253806 WP_257569375.1 NZ_CP102513:c4128478-4128248 [Streptomyces sp. DSM 40750]
MKISVSLPQEDVAFVDEYAERTKADSRSAVIHAAIELLREAQLEQEYTEAFAEWDGSEDAAFWDQFSGDGMTDEAR

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References