Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 5403357..5403922 Replicon chromosome
Accession NZ_CP102509
Organism Streptomyces sp. NBC_00162

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag JIW86_RS25080 Protein ID WP_257556137.1
Coordinates 5403551..5403922 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0M8SFC5
Locus tag JIW86_RS25075 Protein ID WP_053702279.1
Coordinates 5403357..5403554 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIW86_RS25055 (JIW86_25055) 5398658..5400967 + 2310 WP_257556132.1 hypothetical protein -
JIW86_RS25060 (JIW86_25060) 5400967..5401506 + 540 WP_257556134.1 hypothetical protein -
JIW86_RS25070 (JIW86_25070) 5401873..5403324 + 1452 WP_257556136.1 MFS transporter -
JIW86_RS25075 (JIW86_25075) 5403357..5403554 + 198 WP_053702279.1 Arc family DNA-binding protein Antitoxin
JIW86_RS25080 (JIW86_25080) 5403551..5403922 + 372 WP_257556137.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
JIW86_RS25085 (JIW86_25085) 5404052..5405836 + 1785 WP_215144476.1 DEAD/DEAH box helicase -
JIW86_RS25090 (JIW86_25090) 5406266..5406907 + 642 WP_069920456.1 helix-turn-helix domain-containing protein -
JIW86_RS25095 (JIW86_25095) 5407122..5407904 + 783 WP_257559434.1 S16 family serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(32-112)

Antitoxin

Arc-like DNA binding domain

(5-34)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13740.55 Da        Isoelectric Point: 4.6864

>T253803 WP_257556137.1 NZ_CP102509:5403551-5403922 [Streptomyces sp. NBC_00162]
VTHYLTLPEVLNLAERLGTSEVRDYGLLDSALARPQSSVFGQDAYPDIWEKAAALMESLARNHGLVDGNKRIAWYATWVF
LHMNGHPLDADFDVDEAERFVLDVCQGSLDVPKIAAQLPKFAR

Download         Length: 372 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7377.26 Da        Isoelectric Point: 5.6122

>AT253803 WP_053702279.1 NZ_CP102509:5403357-5403554 [Streptomyces sp. NBC_00162]
MAGLNVRFTEEELDALRERAEAEGRSMQSFAHEAVIRAINEHSRLFNEAAEHVLKVSGELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M8SFC5

References