Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3529817..3530342 Replicon chromosome
Accession NZ_CP102509
Organism Streptomyces sp. NBC_00162

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag JIW86_RS16180 Protein ID WP_257554375.1
Coordinates 3530079..3530342 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JIW86_RS16175 Protein ID WP_257554373.1
Coordinates 3529817..3530086 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JIW86_RS16140 (JIW86_16140) 3524874..3525311 - 438 WP_257554362.1 MarR family transcriptional regulator -
JIW86_RS16145 (JIW86_16145) 3525394..3526383 + 990 WP_257554363.1 SMP-30/gluconolactonase/LRE family protein -
JIW86_RS16150 (JIW86_16150) 3526483..3526869 + 387 WP_257554364.1 CPCC family cysteine-rich protein -
JIW86_RS16155 (JIW86_16155) 3526866..3527015 + 150 WP_257554365.1 hypothetical protein -
JIW86_RS16160 (JIW86_16160) 3527039..3527455 + 417 WP_257554369.1 HEAT repeat domain-containing protein -
JIW86_RS16165 (JIW86_16165) 3527573..3528163 - 591 WP_257554371.1 winged helix-turn-helix domain-containing protein -
JIW86_RS16170 (JIW86_16170) 3529032..3529646 + 615 WP_257554372.1 antibiotic biosynthesis monooxygenase -
JIW86_RS16175 (JIW86_16175) 3529817..3530086 + 270 WP_257554373.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
JIW86_RS16180 (JIW86_16180) 3530079..3530342 + 264 WP_257554375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JIW86_RS16185 (JIW86_16185) 3530427..3531515 - 1089 WP_257554378.1 redox-regulated ATPase YchF -
JIW86_RS16190 (JIW86_16190) 3531779..3532168 + 390 WP_251064911.1 hypothetical protein -
JIW86_RS16195 (JIW86_16195) 3532165..3532944 - 780 WP_257554380.1 ROK family protein -
JIW86_RS16200 (JIW86_16200) 3532960..3533952 - 993 WP_257554382.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10052.46 Da        Isoelectric Point: 9.5565

>T253802 WP_257554375.1 NZ_CP102509:3530079-3530342 [Streptomyces sp. NBC_00162]
VSEYRTAFRPEAQAELRKIPRDMALRVLAKLTELESDPFGFNTTALVSQPERRRLRVGDYRFVYTIDNGELVVWVVHVGH
RSTVYGT

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10187.65 Da        Isoelectric Point: 4.7574

>AT253802 WP_257554373.1 NZ_CP102509:3529817-3530086 [Streptomyces sp. NBC_00162]
MTQPLPVESIRDVRAHLAEVVERADRDGVPTVITRRGKEVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References