253801

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 13006..13649 Replicon plasmid pCF10-C
Accession NZ_CP102503
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag NUG39_RS25910 Protein ID WP_065889659.1
Coordinates 13006..13422 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag NUG39_RS25915 Protein ID WP_001261276.1
Coordinates 13419..13649 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS25895 (NUG39_25895) 8872..10215 + 1344 WP_032192047.1 APC family permease -
NUG39_RS25900 (NUG39_25900) 11537..12637 + 1101 WP_032192045.1 NADH:flavin oxidoreductase/NADH oxidase -
NUG39_RS25905 (NUG39_25905) 12725..12970 - 246 WP_045337411.1 hypothetical protein -
NUG39_RS25910 (NUG39_25910) 13006..13422 - 417 WP_065889659.1 type II toxin-antitoxin system VapC family toxin Toxin
NUG39_RS25915 (NUG39_25915) 13419..13649 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NUG39_RS25920 (NUG39_25920) 14223..14573 + 351 WP_000493378.1 hypothetical protein -
NUG39_RS25930 (NUG39_25930) 15417..15734 + 318 WP_047345246.1 DUF305 domain-containing protein -
NUG39_RS25935 (NUG39_25935) 16130..17110 - 981 WP_000019450.1 IS5-like element ISKpn26 family transposase -
NUG39_RS25940 (NUG39_25940) 17322..18230 - 909 WP_001372261.1 HNH endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80740 80740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15064.56 Da        Isoelectric Point: 8.5403

>T253801 WP_065889659.1 NZ_CP102503:c13422-13006 [Citrobacter youngae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT253801 WP_001261276.1 NZ_CP102503:c13649-13419 [Citrobacter youngae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References