Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 37363..37888 Replicon plasmid pCF10-NDM
Accession NZ_CP102502
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name ccdB Uniprot ID W8EAA6
Locus tag NUG39_RS25275 Protein ID WP_008322213.1
Coordinates 37583..37888 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A6C0NE25
Locus tag NUG39_RS25270 Protein ID WP_032934863.1
Coordinates 37363..37581 (+) Length 73 a.a.

Genomic Context

NUG39_RS25250NUG39_RS25260NUG39_RS25265NUG39_RS25270NUG39_RS25275NUG39_RS25280NUG39_RS25285NUG39_RS25255NUG39_RS25290NUG39_RS25295NUG39_RS25305
Location: 32662..32919 (258 bp)
Type: Others
Protein ID: WP_001567333.1
Location: 33864..34790 (927 bp)
Type: Others
Protein ID: WP_257749362.1
Location: 34787..36595 (1809 bp)
Type: Others
Protein ID: WP_032413492.1
Location: 37363..37581 (219 bp)
Type: Antitoxin
Protein ID: WP_032934863.1
Location: 37583..37888 (306 bp)
Type: Toxin
Protein ID: WP_008322213.1
Location: 37890..38204 (315 bp)
Type: Others
Protein ID: WP_008322211.1
Location: 38194..38985 (792 bp)
Type: Others
Protein ID: WP_008322208.1
Location: 33101..33850 (750 bp)
Type: Others
Protein ID: Protein_33
Location: 39184..40524 (1341 bp)
Type: Others
Protein ID: Protein_40
Location: 40668..41414 (747 bp)
Type: Others
Protein ID: Protein_41
Location: 42635..42751 (117 bp)
Type: Others
Protein ID: Protein_43
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
NUG39_RS25250 (NUG39_25250)32662..32919+258WP_001567333.1hypothetical protein-
NUG39_RS25255 (NUG39_25255)33101..33850-750Protein_33IS110-like element IS4321 family transposase-
NUG39_RS25260 (NUG39_25260)33864..34790+927WP_257749362.1SIR2 family protein-
NUG39_RS25265 (NUG39_25265)34787..36595+1809WP_032413492.1ATP-binding protein-
NUG39_RS25270 (NUG39_25270)37363..37581+219WP_032934863.1type II toxin-antitoxin system antitoxin CcdAAntitoxin
NUG39_RS25275 (NUG39_25275)37583..37888+306WP_008322213.1type II toxin-antitoxin system toxin CcdBToxin
NUG39_RS25280 (NUG39_25280)37890..38204+315WP_008322211.1hypothetical protein-
NUG39_RS25285 (NUG39_25285)38194..38985+792WP_008322208.1site-specific integrase-
NUG39_RS25290 (NUG39_25290)39184..40524-1341Protein_40GntP family transporter-
NUG39_RS25295 (NUG39_25295)40668..41414-747Protein_41IS5-like element IS5 family transposase-
NUG39_RS25305 (NUG39_25305)42635..42751-117Protein_43IS5 family transposase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideConjugative plasmidblaNDM-1htpB1..138196138196
-flankIS/Tn--33101..33790689
-insideIScluster/Tn--40668..489128244


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11450.23 Da        Isoelectric Point: 5.8211

>T253798 WP_008322213.1 NZ_CP102502:37583-37888 [Citrobacter youngae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLVSARLLSDKVSRELYPVVSVGGDPYRLMTTDMASVPATVIGEEV
ADLSHLENDIQNAINLMFRGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8297.11 Da        Isoelectric Point: 4.4013

>AT253798 WP_032934863.1 NZ_CP102502:37363-37581 [Citrobacter youngae]
VKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6C0NE27

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A6C0NE25

References