253797

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 5864..6389 Replicon plasmid pCF10-NDM
Accession NZ_CP102502
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name ccdB Uniprot ID A0A6S4YF27
Locus tag NUG39_RS25125 Protein ID WP_025714517.1
Coordinates 5864..6169 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag NUG39_RS25130 Protein ID WP_001568025.1
Coordinates 6171..6389 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS25095 (NUG39_25095) 1543..2169 + 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -
NUG39_RS25100 (NUG39_25100) 2166..2468 + 303 WP_071571079.1 hypothetical protein -
NUG39_RS25105 (NUG39_25105) 2940..3734 - 795 WP_004197635.1 site-specific integrase -
NUG39_RS25110 (NUG39_25110) 3932..4948 - 1017 WP_017899884.1 hypothetical protein -
NUG39_RS25115 (NUG39_25115) 4959..5273 - 315 WP_053389906.1 hypothetical protein -
NUG39_RS25120 (NUG39_25120) 5300..5695 - 396 WP_017899885.1 hypothetical protein -
NUG39_RS25125 (NUG39_25125) 5864..6169 - 306 WP_025714517.1 type II toxin-antitoxin system toxin CcdB Toxin
NUG39_RS25130 (NUG39_25130) 6171..6389 - 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
NUG39_RS25135 (NUG39_25135) 6969..7538 + 570 WP_016162066.1 hypothetical protein -
NUG39_RS25140 (NUG39_25140) 7679..8707 + 1029 WP_001568023.1 Abi family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaNDM-1 htpB 1..138196 138196


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11562.25 Da        Isoelectric Point: 5.6906

>T253797 WP_025714517.1 NZ_CP102502:c6169-5864 [Citrobacter youngae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSCELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT253797 WP_001568025.1 NZ_CP102502:c6389-6171 [Citrobacter youngae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6S4YF27

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References