253796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 125050..125576 Replicon plasmid pCF10-tmexCD1
Accession NZ_CP102501
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NUG39_RS24695 Protein ID WP_000323025.1
Coordinates 125050..125337 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUG39_RS24700 Protein ID WP_204628246.1
Coordinates 125337..125576 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS24665 (NUG39_24665) 120277..120543 + 267 WP_035896700.1 DUF1778 domain-containing protein -
NUG39_RS24670 (NUG39_24670) 120531..121013 + 483 WP_035896699.1 GNAT family N-acetyltransferase -
NUG39_RS24675 (NUG39_24675) 121220..122566 + 1347 WP_257749353.1 ISNCY family transposase -
NUG39_RS24680 (NUG39_24680) 122615..123013 + 399 WP_047665785.1 helix-turn-helix domain-containing protein -
NUG39_RS24685 (NUG39_24685) 123156..123908 - 753 Protein_120 IS3-like element ISKpn38 family transposase -
NUG39_RS24690 (NUG39_24690) 123972..124940 - 969 WP_220439822.1 IS5 family transposase -
NUG39_RS24695 (NUG39_24695) 125050..125337 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NUG39_RS24700 (NUG39_24700) 125337..125576 - 240 WP_204628246.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUG39_RS24705 (NUG39_24705) 125601..125702 + 102 Protein_124 protein YdfV -
NUG39_RS24710 (NUG39_24710) 125799..126496 + 698 WP_101780539.1 IS1 family transposase -
NUG39_RS24715 (NUG39_24715) 126701..127021 - 321 WP_004197483.1 hypothetical protein -
NUG39_RS24720 (NUG39_24720) 127322..128026 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NUG39_RS24725 (NUG39_24725) 128430..129134 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
NUG39_RS24730 (NUG39_24730) 129171..129674 - 504 WP_013851371.1 shikimate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaTEM-1B / mph(A) / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 / qnrS1 - 1..212154 212154
- inside IScluster/Tn mph(A) / tet(A) / aph(6)-Id / aph(3'')-Ib / sul2 / mph(E) / msr(E) / armA / sul1 / qacE / aadA2 / dfrA12 - 109958..152463 42505


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T253796 WP_000323025.1 NZ_CP102501:c125337-125050 [Citrobacter youngae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9098.50 Da        Isoelectric Point: 4.5230

>AT253796 WP_204628246.1 NZ_CP102501:c125576-125337 [Citrobacter youngae]
MGNINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure

References