253791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/COG3657-dnstrm_HI1420
Location 4686776..4687364 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag NUG39_RS22550 Protein ID WP_257749332.1
Coordinates 4686776..4687093 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag NUG39_RS22555 Protein ID WP_048213961.1
Coordinates 4687086..4687364 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS22515 (4682555) 4682555..4683367 + 813 WP_257748462.1 shikimate 5-dehydrogenase -
NUG39_RS22520 (4683401) 4683401..4683718 - 318 WP_257748463.1 CcdB family protein -
NUG39_RS22525 (4683718) 4683718..4684011 - 294 WP_032947883.1 type II toxin-antitoxin system CcdA family antitoxin -
NUG39_RS22530 (4684108) 4684108..4684473 - 366 WP_137376781.1 hypothetical protein -
NUG39_RS22535 (4684615) 4684615..4684776 + 162 WP_003841416.1 phage protein -
NUG39_RS22540 (4685214) 4685214..4685564 + 351 WP_257748464.1 hypothetical protein -
NUG39_RS22545 (4685659) 4685659..4686219 + 561 WP_257748466.1 hypothetical protein -
NUG39_RS22550 (4686776) 4686776..4687093 + 318 WP_257749332.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG39_RS22555 (4687086) 4687086..4687364 + 279 WP_048213961.1 putative addiction module antidote protein Antitoxin
NUG39_RS22560 (4687464) 4687464..4688153 + 690 WP_003841421.1 dipeptidase PepE -
NUG39_RS22565 (4688282) 4688282..4689910 - 1629 WP_257748468.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11984.85 Da        Isoelectric Point: 9.8851

>T253791 WP_257749332.1 NZ_CP102500:4686776-4687093 [Citrobacter youngae]
IMEILQTTVFQRWEQNLRDRRAKTLIAARLFRLANGLAGDVKPVGEGVSEMRISYGPGYRIYFKQHGCRIIILLCGGDKS
SQANDITLAKVLARSLDYQETFRHE

Download         Length: 318 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 9764.31 Da        Isoelectric Point: 6.2976

>AT253791 WP_048213961.1 NZ_CP102500:4687086-4687364 [Citrobacter youngae]
MNKLTQYDPAAALVDDEEIAVFMADALETGDATYIAKALGVVARAKGMASIAAETGLSREQLYRSFSEKGNPTLKTTLAV
MKALGIGLTLRK

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References