Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4432132..4432648 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name relE Uniprot ID A0A0D7LMW6
Locus tag NUG39_RS21340 Protein ID WP_003839578.1
Coordinates 4432132..4432416 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0J1MV10
Locus tag NUG39_RS21345 Protein ID WP_003839576.1
Coordinates 4432406..4432648 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS21325 (4427358) 4427358..4429010 + 1653 WP_257748406.1 alpha,alpha-phosphotrehalase -
NUG39_RS21330 (4429419) 4429419..4431557 + 2139 WP_048212844.1 anaerobic ribonucleoside-triphosphate reductase -
NUG39_RS21335 (4431664) 4431664..4432128 + 465 WP_048212845.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NUG39_RS21340 (4432132) 4432132..4432416 - 285 WP_003839578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUG39_RS21345 (4432406) 4432406..4432648 - 243 WP_003839576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NUG39_RS21350 (4432726) 4432726..4434639 - 1914 WP_257748410.1 BglG family transcription antiterminator -
NUG39_RS21355 (4434661) 4434661..4435401 - 741 WP_048212847.1 KDGP aldolase family protein -
NUG39_RS21360 (4435398) 4435398..4436516 - 1119 WP_116361061.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NUG39_RS21365 (4436500) 4436500..4437633 - 1134 WP_257748412.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10866.68 Da        Isoelectric Point: 10.0482

>T253789 WP_003839578.1 NZ_CP102500:c4432416-4432132 [Citrobacter youngae]
MTYELEFDPRALKEWHKLGDTVKAQFKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVTVFVVAVGK
REHSAVYLDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT253789 WP_003839576.1 NZ_CP102500:c4432648-4432406 [Citrobacter youngae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDTLIQTVRERLASPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D7LMW6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MV10

References