Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3738743..3739363 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NUG39_RS18090 Protein ID WP_002892050.1
Coordinates 3739145..3739363 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NUG39_RS18085 Protein ID WP_003021733.1
Coordinates 3738743..3739117 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS18075 (3733890) 3733890..3735083 + 1194 WP_200044605.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NUG39_RS18080 (3735106) 3735106..3738255 + 3150 WP_048212411.1 efflux RND transporter permease AcrB -
NUG39_RS18085 (3738743) 3738743..3739117 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NUG39_RS18090 (3739145) 3739145..3739363 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NUG39_RS18095 (3739552) 3739552..3740103 + 552 WP_115600829.1 maltose O-acetyltransferase -
NUG39_RS18100 (3740220) 3740220..3740690 + 471 WP_040232692.1 YlaC family protein -
NUG39_RS18105 (3740768) 3740768..3740908 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NUG39_RS18110 (3740910) 3740910..3741170 - 261 WP_005125189.1 type B 50S ribosomal protein L31 -
NUG39_RS18115 (3741359) 3741359..3742912 + 1554 WP_048212413.1 EAL domain-containing protein -
NUG39_RS18120 (3742967) 3742967..3743320 - 354 WP_061067436.1 DUF1428 family protein -
NUG39_RS18125 (3743403) 3743403..3744014 - 612 WP_061067435.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253786 WP_002892050.1 NZ_CP102500:3739145-3739363 [Citrobacter youngae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT253786 WP_003021733.1 NZ_CP102500:3738743-3739117 [Citrobacter youngae]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References