Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4054493..4055232 Replicon chromosome
Accession NC_015663
Organism Enterobacter aerogenes KCTC 2190

Toxin (Protein)


Gene name tacT Uniprot ID A0A0H3G0L6
Locus tag EAE_RS19150 Protein ID WP_015705365.1
Coordinates 4054493..4054978 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A0H3FSM9
Locus tag EAE_RS19155 Protein ID WP_015705366.1
Coordinates 4054966..4055232 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE_RS19130 4050040..4051110 - 1071 WP_015705361.1 mannonate dehydratase -
EAE_RS19135 4051371..4051529 + 159 WP_015705362.1 YqaE/Pmp3 family membrane protein -
EAE_RS19140 4051586..4052686 - 1101 WP_015705363.1 NADH:flavin oxidoreductase/NADH oxidase -
EAE_RS19145 4052805..4054421 - 1617 WP_015705364.1 FAD-NAD(P)-binding protein -
EAE_RS19150 4054493..4054978 - 486 WP_015705365.1 GNAT family N-acetyltransferase Toxin
EAE_RS19155 4054966..4055232 - 267 WP_015705366.1 DUF1778 domain-containing protein Antitoxin
EAE_RS19160 4055505..4056740 + 1236 WP_015705367.1 MFS transporter -
EAE_RS19165 4056784..4057281 - 498 WP_015705368.1 heme-binding protein -
EAE_RS19170 4057377..4057994 - 618 WP_015705369.1 response regulator transcription factor -
EAE_RS19175 4057994..4059313 - 1320 WP_015705370.1 two-component sensor histidine kinase -
EAE_RS19180 4059310..4059897 - 588 WP_015705371.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(27-151)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17603.25 Da        Isoelectric Point: 8.8590

>T25378 WP_015705365.1 NC_015663:c4054978-4054493 [Klebsiella aerogenes KCTC 2190]
MGKISAPAPLSSHHQIAEFCCGETVLDQWLKQRGLKNQAQGAARTFVVCKEESHQVVGFYSLATGSVNHTEATGGLRRNM
PDPIPVIILARLAIDCAYHGQGLGADLLHDALLRSYRVAENVGVRALMVHALTDSAKRFYLHHGFKASTTQERTLFLALP
K

Download         Length: 486 bp

>T25378 NC_015663:c4054978-4054493 [Klebsiella aerogenes KCTC 2190]
ATGGGAAAAATAAGCGCGCCTGCACCGCTATCTTCACACCATCAGATCGCGGAATTTTGTTGTGGAGAAACGGTTCTCGA
TCAATGGCTGAAACAGCGAGGATTGAAAAACCAGGCTCAGGGCGCCGCGAGAACCTTTGTGGTCTGCAAGGAAGAGAGCC
ATCAGGTGGTGGGGTTTTATTCGTTAGCAACCGGCAGCGTTAATCACACGGAAGCCACTGGCGGCCTGCGGCGCAATATG
CCCGATCCTATCCCGGTCATCATTCTCGCCCGCCTGGCGATCGACTGCGCGTATCACGGACAGGGGCTGGGAGCTGATTT
ACTCCATGATGCGCTCTTACGCAGTTATCGCGTTGCCGAAAATGTTGGCGTTCGTGCCCTGATGGTCCATGCCCTGACCG
ATAGCGCGAAGCGATTCTATTTACACCACGGATTCAAAGCCTCCACCACCCAGGAACGCACACTTTTCCTCGCGTTGCCT
AAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10085.56 Da        Isoelectric Point: 4.6558

>AT25378 WP_015705366.1 NC_015663:c4055232-4054966 [Klebsiella aerogenes KCTC 2190]
MKSDIQLNIRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNLSDEQYAEFIDMLDAPVEANPALDKLL
ARKPQWEK

Download         Length: 267 bp

>AT25378 NC_015663:c4055232-4054966 [Klebsiella aerogenes KCTC 2190]
ATGAAATCAGATATCCAACTCAACATCCGGGCGAAGGAGTCCCAGCGGGCGCTGATTGATGCGGCTGCCGAAATTCTGCA
CAAATCACGGACCGACTTTATTCTTGAGATGGCCTGCCAGGCGGCAGAAAACGTAATTCTCGACCGCCGGGTGTTTAACT
TAAGCGATGAGCAATACGCCGAATTTATCGACATGCTGGATGCGCCGGTTGAAGCTAACCCCGCTCTCGATAAATTGCTG
GCGAGAAAACCGCAATGGGAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3G0L6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FSM9

References