253778

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 823498..824301 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name yeeV Uniprot ID A0A6N6JYU3
Locus tag NUG39_RS04020 Protein ID WP_024156451.1
Coordinates 823498..823878 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A5A9BSL8
Locus tag NUG39_RS04025 Protein ID WP_038807908.1
Coordinates 823936..824301 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS03990 (819132) 819132..819668 + 537 WP_061068568.1 type VI secretion system lipoprotein TssJ -
NUG39_RS03995 (819665) 819665..820108 + 444 WP_061068567.1 type VI secretion system baseplate subunit TssE -
NUG39_RS04000 (820110) 820110..821450 + 1341 WP_257748798.1 VasL domain-containing protein -
NUG39_RS04005 (821854) 821854..822701 - 848 Protein_786 DUF4942 domain-containing protein -
NUG39_RS04010 (822784) 822784..822980 - 197 Protein_787 hypothetical protein -
NUG39_RS04015 (823010) 823010..823501 - 492 WP_024156452.1 DUF5983 family protein -
NUG39_RS04020 (823498) 823498..823878 - 381 WP_024156451.1 TA system toxin CbtA family protein Toxin
NUG39_RS04025 (823936) 823936..824301 - 366 WP_038807908.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NUG39_RS04030 (824323) 824323..824544 - 222 WP_024156449.1 DUF987 domain-containing protein -
NUG39_RS04035 (824558) 824558..825037 - 480 WP_024156448.1 DNA repair protein RadC -
NUG39_RS04040 (825050) 825050..825523 - 474 WP_024156447.1 antirestriction protein -
NUG39_RS04045 (825792) 825792..826610 - 819 WP_048242033.1 DUF932 domain-containing protein -
NUG39_RS04050 (826726) 826726..826995 - 270 WP_191213934.1 DUF905 family protein -
NUG39_RS04055 (827186) 827186..827653 - 468 WP_048242036.1 hypothetical protein -
NUG39_RS04060 (827750) 827750..828151 - 402 WP_048242038.1 hypothetical protein -
NUG39_RS04065 (828357) 828357..829244 - 888 WP_170975175.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-110)

Antitoxin

Antitoxin CbeA

(15-114)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14263.44 Da        Isoelectric Point: 10.0919

>T253778 WP_024156451.1 NZ_CP102500:c823878-823498 [Citrobacter youngae]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS

Download         Length: 381 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13344.20 Da        Isoelectric Point: 5.8705

>AT253778 WP_038807908.1 NZ_CP102500:c824301-823936 [Citrobacter youngae]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6N6JYU3

Antitoxin

Source ID Structure
AlphaFold DB A0A5A9BSL8

References