Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 702322..703001 Replicon chromosome
Accession NZ_CP102500
Organism Citrobacter youngae strain CF10

Toxin (Protein)


Gene name ykfI Uniprot ID A0A7D6Z078
Locus tag NUG39_RS03470 Protein ID WP_048215514.1
Coordinates 702660..703001 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0F6RHY7
Locus tag NUG39_RS03465 Protein ID WP_046495841.1
Coordinates 702322..702639 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUG39_RS03425 (697881) 697881..698714 + 834 WP_048215513.1 DUF932 domain-containing protein -
NUG39_RS03430 (698916) 698916..699620 + 705 WP_046495813.1 WYL domain-containing protein -
NUG39_RS03435 (699617) 699617..700231 + 615 WP_046495819.1 hypothetical protein -
NUG39_RS03440 (700320) 700320..700730 + 411 WP_257748768.1 hypothetical protein -
NUG39_RS03445 (700808) 700808..701044 + 237 WP_046495830.1 DUF905 domain-containing protein -
NUG39_RS03450 (701123) 701123..701581 + 459 WP_046495834.1 antirestriction protein -
NUG39_RS03455 (701597) 701597..702073 + 477 WP_257748769.1 RadC family protein -
NUG39_RS03460 (702082) 702082..702303 + 222 WP_000691995.1 DUF987 domain-containing protein -
NUG39_RS03465 (702322) 702322..702639 + 318 WP_046495841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
NUG39_RS03470 (702660) 702660..703001 + 342 WP_048215514.1 TA system toxin CbtA family protein Toxin
NUG39_RS03475 (703117) 703117..703950 + 834 WP_046495848.1 DUF4942 domain-containing protein -
NUG39_RS03485 (704253) 704253..704759 + 507 WP_048213266.1 G/U mismatch-specific DNA glycosylase -
NUG39_RS03490 (704805) 704805..706652 - 1848 WP_003024699.1 RNA polymerase sigma factor RpoD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 684109..703001 18892


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13014.97 Da        Isoelectric Point: 10.4182

>T253777 WP_048215514.1 NZ_CP102500:702660-703001 [Citrobacter youngae]
MKPQSAATSRAVKPCLSPVAIWQILLTRLLEQHYGLTLNDTPFRDESVIQEHIDAGITLANAVNFLVEKYELVRIDRRRF
SWQEQSPYLRAADILRARQATGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11869.49 Da        Isoelectric Point: 6.6245

>AT253777 WP_046495841.1 NZ_CP102500:702322-702639 [Citrobacter youngae]
MSNITWGLQRDITPRLGTRLVQEGNRLHYLADRASITGKFSDAECQKLDETFPHFISQMESMLTSGELNPLHVHCVTLYH
TGFTCEADTLGSCGYVYIAIYPTKR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6Z078

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6RHY7

References