Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 59031..59767 Replicon plasmid pIncFIBK
Accession NZ_CP102492
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name tacT Uniprot ID A0A8T5ZF70
Locus tag LCN95_RS26935 Protein ID WP_004187044.1
Coordinates 59031..59513 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag LCN95_RS26940 Protein ID WP_003026799.1
Coordinates 59501..59767 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS26915 (LCN95_26920) 54327..55031 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
LCN95_RS26920 (LCN95_26925) 55191..56537 - 1347 WP_077251107.1 ISNCY family transposase -
LCN95_RS26925 (LCN95_26930) 56767..57399 + 633 WP_001567369.1 hypothetical protein -
LCN95_RS26930 (LCN95_26935) 57428..58831 - 1404 WP_001272054.1 ISNCY-like element ISKpn21 family transposase -
LCN95_RS26935 (LCN95_26940) 59031..59513 - 483 WP_004187044.1 GNAT family N-acetyltransferase Toxin
LCN95_RS26940 (LCN95_26945) 59501..59767 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
LCN95_RS26945 (LCN95_26950) 59918..60622 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
LCN95_RS26950 (LCN95_26955) 60781..63366 - 2586 WP_004187040.1 EAL domain-containing protein -
LCN95_RS26955 (LCN95_26960) 63335..63580 - 246 WP_032238678.1 hypothetical protein -
LCN95_RS26960 (LCN95_26965) 63638..64618 - 981 Protein_64 IS5-like element ISKpn26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - mrkA / mrkB / mrkC / mrkF / mrkJ 1..112905 112905
- inside IScluster/Tn - - 50599..64618 14019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(46-148)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17280.93 Da        Isoelectric Point: 8.7197

>T253775 WP_004187044.1 NZ_CP102492:c59513-59031 [Klebsiella pneumoniae]
VGCITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTYERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT253775 WP_003026799.1 NZ_CP102492:c59767-59501 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References