Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5246608..5247233 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag LCN95_RS25355 Protein ID WP_019705794.1
Coordinates 5246608..5246991 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LCN95_RS25360 Protein ID WP_004150355.1
Coordinates 5246991..5247233 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS25340 (LCN95_25345) 5243974..5244876 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LCN95_RS25345 (LCN95_25350) 5244873..5245508 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LCN95_RS25350 (LCN95_25355) 5245505..5246434 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LCN95_RS25355 (LCN95_25360) 5246608..5246991 - 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
LCN95_RS25360 (LCN95_25365) 5246991..5247233 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LCN95_RS25365 (LCN95_25370) 5247438..5248355 + 918 WP_019705795.1 alpha/beta hydrolase -
LCN95_RS25370 (LCN95_25375) 5248369..5249310 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LCN95_RS25375 (LCN95_25380) 5249355..5249792 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LCN95_RS25380 (LCN95_25385) 5249789..5250649 - 861 WP_004146232.1 virulence factor BrkB family protein -
LCN95_RS25385 (LCN95_25390) 5250643..5251242 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T253774 WP_019705794.1 NZ_CP102490:c5246991-5246608 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT253774 WP_004150355.1 NZ_CP102490:c5247233-5246991 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References