Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4923111..4924792 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name mosT Uniprot ID A0A2L0KL13
Locus tag LCN95_RS23860 Protein ID WP_019704723.1
Coordinates 4923111..4924028 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A6TH05
Locus tag LCN95_RS23865 Protein ID WP_004177809.1
Coordinates 4924034..4924792 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS23840 (LCN95_23845) 4918417..4919937 + 1521 WP_004210021.1 sugar ABC transporter ATP-binding protein -
LCN95_RS23845 (LCN95_23850) 4919934..4920932 + 999 WP_002885172.1 ribose ABC transporter permease -
LCN95_RS23850 (LCN95_23855) 4920963..4921904 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
LCN95_RS23855 (LCN95_23860) 4921979..4922986 + 1008 WP_004178300.1 carbohydrate kinase family protein -
LCN95_RS23860 (LCN95_23865) 4923111..4924028 - 918 WP_019704723.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
LCN95_RS23865 (LCN95_23870) 4924034..4924792 - 759 WP_004177809.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
LCN95_RS23870 (LCN95_23875) 4924878..4925606 - 729 WP_002885152.1 response regulator transcription factor -
LCN95_RS23875 (LCN95_23880) 4925879..4928026 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
LCN95_RS23880 (LCN95_23885) 4928023..4928166 - 144 WP_019704724.1 hypothetical protein -
LCN95_RS23885 (LCN95_23890) 4928372..4929058 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34632.07 Da        Isoelectric Point: 5.4707

>T253773 WP_019704723.1 NZ_CP102490:c4924028-4923111 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28548.92 Da        Isoelectric Point: 10.0870

>AT253773 WP_004177809.1 NZ_CP102490:c4924792-4924034 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L0KL13

Antitoxin

Source ID Structure
AlphaFold DB A6TH05

References