Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4762124..4762640 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag LCN95_RS23055 Protein ID WP_009486548.1
Coordinates 4762124..4762408 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A331AB37
Locus tag LCN95_RS23060 Protein ID WP_019704689.1
Coordinates 4762398..4762640 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS23030 (LCN95_23035) 4757520..4757783 - 264 WP_020802733.1 PTS sugar transporter subunit IIB -
LCN95_RS23035 (LCN95_23040) 4757913..4758026 + 114 Protein_4514 hypothetical protein -
LCN95_RS23040 (LCN95_23045) 4758089..4758832 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
LCN95_RS23045 (LCN95_23050) 4759189..4761327 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
LCN95_RS23050 (LCN95_23055) 4761656..4762120 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCN95_RS23055 (LCN95_23060) 4762124..4762408 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCN95_RS23060 (LCN95_23065) 4762398..4762640 - 243 WP_019704689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCN95_RS23065 (LCN95_23070) 4762718..4764628 - 1911 WP_004152270.1 PRD domain-containing protein -
LCN95_RS23070 (LCN95_23075) 4764651..4765805 - 1155 WP_019704690.1 lactonase family protein -
LCN95_RS23075 (LCN95_23080) 4765872..4766612 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T253772 WP_009486548.1 NZ_CP102490:c4762408-4762124 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9044.56 Da        Isoelectric Point: 8.5313

>AT253772 WP_019704689.1 NZ_CP102490:c4762640-4762398 [Klebsiella pneumoniae]
MATLNVRLDDKLKKQAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A331AB37

References