Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2639066..2640654 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LCN95_RS12995 Protein ID WP_019705665.1
Coordinates 2639066..2640388 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LCN95_RS13000 Protein ID WP_004176198.1
Coordinates 2640388..2640654 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS12980 (LCN95_12985) 2634122..2636623 + 2502 WP_064181310.1 fimbria/pilus outer membrane usher protein -
LCN95_RS12985 (LCN95_12990) 2636611..2637615 + 1005 WP_004184029.1 fimbrial protein -
LCN95_RS12990 (LCN95_12995) 2637757..2639049 + 1293 WP_267272346.1 glycoside hydrolase family 10 protein -
LCN95_RS12995 (LCN95_13000) 2639066..2640388 - 1323 WP_019705665.1 type II toxin-antitoxin system HipA family toxin Toxin
LCN95_RS13000 (LCN95_13005) 2640388..2640654 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
LCN95_RS13005 (LCN95_13010) 2640920..2641246 - 327 WP_019705664.1 hydroxyisourate hydrolase -
LCN95_RS13010 (LCN95_13015) 2641243..2641743 - 501 WP_019705663.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
LCN95_RS13015 (LCN95_13020) 2641721..2643100 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
LCN95_RS13020 (LCN95_13025) 2643446..2644600 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
LCN95_RS13025 (LCN95_13030) 2644581..2645504 - 924 WP_019705662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - mgtC / iroE 2434814..2676395 241581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49155.46 Da        Isoelectric Point: 7.5358

>T253768 WP_019705665.1 NZ_CP102490:c2640388-2639066 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT253768 WP_004176198.1 NZ_CP102490:c2640654-2640388 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References