Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 785180..785837 Replicon chromosome
Accession NZ_CP102490
Organism Klebsiella pneumoniae strain BA13643

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LCN95_RS03900 Protein ID WP_002916310.1
Coordinates 785427..785837 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LCN95_RS03895 Protein ID WP_002916312.1
Coordinates 785180..785446 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCN95_RS03870 (LCN95_03870) 780388..781821 - 1434 WP_267272298.1 6-phospho-beta-glucosidase BglA -
LCN95_RS03875 (LCN95_03875) 781940..782668 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LCN95_RS03880 (LCN95_03880) 782718..783029 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LCN95_RS03885 (LCN95_03885) 783193..783852 + 660 WP_002916317.1 hemolysin III family protein -
LCN95_RS03890 (LCN95_03890) 783951..784934 - 984 WP_016530681.1 tRNA-modifying protein YgfZ -
LCN95_RS03895 (LCN95_03895) 785180..785446 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LCN95_RS03900 (LCN95_03900) 785427..785837 + 411 WP_002916310.1 protein YgfX Toxin
LCN95_RS03905 (LCN95_03905) 785844..786365 - 522 WP_004144730.1 flavodoxin FldB -
LCN95_RS03910 (LCN95_03910) 786466..787362 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LCN95_RS03915 (LCN95_03915) 787385..788098 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LCN95_RS03920 (LCN95_03920) 788104..789837 + 1734 WP_019704911.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T253763 WP_002916310.1 NZ_CP102490:785427-785837 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT253763 WP_002916312.1 NZ_CP102490:785180-785446 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References