Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 1378361..1379028 Replicon chromosome
Accession NC_015663
Organism Enterobacter aerogenes KCTC 2190

Toxin (Protein)


Gene name ypjF Uniprot ID A0A0H3FNF1
Locus tag EAE_RS06705 Protein ID WP_015703842.1
Coordinates 1378708..1379028 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0H3FLG0
Locus tag EAE_RS06700 Protein ID WP_015703841.1
Coordinates 1378361..1378687 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE_RS06675 1374050..1374943 + 894 WP_015703836.1 50S ribosome-binding GTPase -
EAE_RS06680 1375135..1375824 + 690 WP_015703837.1 WYL domain-containing protein -
EAE_RS06685 1375886..1376896 + 1011 WP_015703838.1 hypothetical protein -
EAE_RS06690 1376989..1377810 + 822 WP_015703839.1 DUF945 domain-containing protein -
EAE_RS06695 1377878..1378348 + 471 WP_015703840.1 DNA repair protein RadC -
EAE_RS06700 1378361..1378687 + 327 WP_015703841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
EAE_RS06705 1378708..1379028 + 321 WP_015703842.1 TA system toxin CbtA family protein Toxin
EAE_RS06710 1379275..1379841 + 567 WP_015703843.1 hypothetical protein -
EAE_RS06715 1379857..1380051 - 195 WP_015703844.1 toxin-antitoxin system HicB family antitoxin -
EAE_RS06720 1380188..1380475 + 288 WP_015703845.1 SymE family type I addiction module toxin -
EAE_RS06725 1380699..1381736 + 1038 WP_015703846.1 virulence RhuM family protein -
EAE_RS06730 1382021..1383217 - 1197 WP_015703847.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1364836..1381736 16900


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-98)

Antitoxin

Antitoxin CbeA

(7-107)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12106.95 Da        Isoelectric Point: 5.5873

>T25376 WP_015703842.1 NC_015663:1378708-1379028 [Klebsiella aerogenes KCTC 2190]
MNTQPATTPQAAKPCLSPLAVWKMLLTILLDQHYGLTLNDTPFSDETVIQKHIEAGITLADAINFLVERYELVRIDQKGF
SVQDQEPWLTSMDVHRARFKLNVERL

Download         Length: 321 bp

>T25376 NC_015663:1378708-1379028 [Klebsiella aerogenes KCTC 2190]
ATGAATACTCAACCTGCAACAACTCCGCAGGCGGCGAAGCCATGTCTGTCGCCCCTGGCTGTCTGGAAAATGTTACTGAC
AATCCTGCTAGACCAGCACTATGGTCTCACGCTAAACGACACGCCGTTCAGTGATGAAACTGTTATTCAGAAACACATTG
AGGCAGGTATTACCTTGGCTGATGCCATAAATTTTCTGGTTGAACGCTATGAACTAGTTCGTATTGACCAAAAAGGCTTC
TCTGTGCAAGATCAAGAACCTTGGTTAACTTCTATGGATGTCCACCGAGCACGATTTAAACTCAACGTGGAACGTTTATA
A

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12268.98 Da        Isoelectric Point: 6.2003

>AT25376 WP_015703841.1 NC_015663:1378361-1378687 [Klebsiella aerogenes KCTC 2190]
MSLIPAHEWGLQREIVPRFGARLVQEGNRLHYLADRASLMGNFSDTECFKLNDAFPHFISQMESMLTTGELIPCHQHCVT
LYHNGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 327 bp

>AT25376 NC_015663:1378361-1378687 [Klebsiella aerogenes KCTC 2190]
ATGTCATTAATACCAGCCCATGAATGGGGACTACAAAGAGAAATTGTTCCACGGTTTGGTGCCAGATTAGTTCAGGAAGG
CAACCGGCTGCATTATCTGGCTGACAGGGCTAGTTTGATGGGCAATTTCAGCGATACGGAATGTTTCAAATTGAATGACG
CATTTCCACACTTTATCAGCCAGATGGAATCGATGCTGACCACTGGTGAACTGATCCCCTGTCACCAACACTGTGTCACT
CTCTACCACAACGGTTTTACCTGCGAAGCTGACACCCTTGGCAGTTGCGGCTACGTGTACATCGCTGTTTACCCTACTCA
ACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FNF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FLG0

References