Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1774..2333 Replicon plasmid p113Kb
Accession NZ_CP102489
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NUI00_RS25970 Protein ID WP_001620845.1
Coordinates 2058..2333 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUI00_RS25965 Protein ID WP_024188746.1
Coordinates 1774..2058 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS25960 (1) 1..858 + 858 WP_001774315.1 incFII family plasmid replication initiator RepA -
NUI00_RS25965 (1774) 1774..2058 + 285 WP_024188746.1 ribbon-helix-helix domain-containing protein Antitoxin
NUI00_RS25970 (2058) 2058..2333 + 276 WP_001620845.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUI00_RS25975 (2439) 2439..2642 + 204 Protein_3 hypothetical protein -
NUI00_RS25980 (3171) 3171..3407 + 237 WP_032257624.1 colicin V immunity protein -
NUI00_RS25985 (3577) 3577..3870 + 294 WP_001620849.1 DUF6404 family protein -
NUI00_RS25990 (3948) 3948..4249 - 302 Protein_6 hypothetical protein -
NUI00_RS25995 (4430) 4430..5464 + 1035 WP_257739443.1 3-deoxy-7-phosphoheptulonate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iroN / iroE / iroD / iroC / iroB 1..113589 113589


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10763.47 Da        Isoelectric Point: 9.9324

>T253759 WP_001620845.1 NZ_CP102489:2058-2333 [Escherichia coli O15:H18]
MELKWTSKALSDLARLYDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREIRRIFAGEYEIRYELNGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10446.88 Da        Isoelectric Point: 5.6558

>AT253759 WP_024188746.1 NZ_CP102489:1774-2058 [Escherichia coli O15:H18]
MQMKNNTAQATKVITAHVPLPMADKVDQMAAKLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References