253753

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3938080..3938692 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name hicA Uniprot ID U9YXE2
Locus tag NUI00_RS19095 Protein ID WP_000833473.1
Coordinates 3938080..3938265 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID L4IWR9
Locus tag NUI00_RS19100 Protein ID WP_000499744.1
Coordinates 3938282..3938692 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS19085 (3934912) 3934912..3936063 + 1152 WP_000741501.1 L-threonine dehydrogenase -
NUI00_RS19090 (3936264) 3936264..3937802 + 1539 WP_001309845.1 aldehyde dehydrogenase AldB -
NUI00_RS19095 (3938080) 3938080..3938265 + 186 WP_000833473.1 type II toxin-antitoxin system HicA family toxin Toxin
NUI00_RS19100 (3938282) 3938282..3938692 + 411 WP_000499744.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NUI00_RS19105 (3938764) 3938764..3940728 - 1965 WP_001026861.1 glycoside hydrolase family 127 protein -
NUI00_RS19110 (3940739) 3940739..3942139 - 1401 WP_000204802.1 MFS transporter -
NUI00_RS19115 (3942365) 3942365..3943180 + 816 WP_000891825.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 6800.89 Da        Isoelectric Point: 11.7053

>T253753 WP_000833473.1 NZ_CP102488:3938080-3938265 [Escherichia coli O15:H18]
VKSADVIAILKQHGWEHIRTRGSHHQFRHPVHPGLVTVPHPKKDIKPGTLAQIGRQAGLTF

Download         Length: 186 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15241.15 Da        Isoelectric Point: 4.5486

>AT253753 WP_000499744.1 NZ_CP102488:3938282-3938692 [Escherichia coli O15:H18]
MFYPAYIHSDPDGSASGFFPDVPGCYFAGDTLDNAFQDARSALVAHFETLCEMNEELPLPGSVETHLVQRAQDFIGGQWL
LVDINMNQFEGRAERINITMPKRLLNKIDTYVRNNPDYANRSAFLAEAARRVLPGV

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YXE2

Antitoxin

Source ID Structure
AlphaFold DB L4IWR9

References