Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1181372..1182003 Replicon chromosome
Accession NC_015663
Organism Enterobacter aerogenes KCTC 2190

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H3FL31
Locus tag EAE_RS05830 Protein ID WP_015703741.1
Coordinates 1181728..1182003 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0H3FNK6
Locus tag EAE_RS05825 Protein ID WP_015703740.1
Coordinates 1181372..1181731 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE_RS05800 1177629..1178573 + 945 WP_015703735.1 nickel ABC transporter permease subunit NikB -
EAE_RS05805 1178570..1179403 + 834 WP_015703736.1 nickel ABC transporter permease subunit NikC -
EAE_RS05810 1179403..1180167 + 765 WP_015703737.1 nickel import ATP-binding protein NikD -
EAE_RS05815 1180164..1180955 + 792 WP_015703738.1 nickel import ATP-binding protein NikE -
EAE_RS05820 1180943..1181344 + 402 WP_015703739.1 nickel-responsive transcriptional regulator NikR -
EAE_RS05825 1181372..1181731 - 360 WP_015703740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
EAE_RS05830 1181728..1182003 - 276 WP_015703741.1 type II toxin-antitoxin system HicA family toxin Toxin
EAE_RS05835 1182400..1183413 + 1014 WP_015369274.1 magnesium transporter -
EAE_RS05840 1183454..1184647 - 1194 WP_015703742.1 NAD(P)/FAD-dependent oxidoreductase -
EAE_RS05845 1184878..1186374 + 1497 WP_015369272.1 inorganic phosphate transporter PitA -
EAE_RS05850 1186439..1186774 - 336 WP_015703743.1 universal stress protein UspB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10258.89 Da        Isoelectric Point: 10.4888

>T25375 WP_015703741.1 NC_015663:c1182003-1181728 [Klebsiella aerogenes KCTC 2190]
MEQQVLSLRKKQRNTLEQLFKTPVPQGIKWADIESLIKALGGEIKEGRGSRCKFLLNHSIASFHRPHPSPDTDKGAVESV
RDWLITIGVKP

Download         Length: 276 bp

>T25375 NC_015663:c1182003-1181728 [Klebsiella aerogenes KCTC 2190]
ATGGAGCAGCAGGTTTTATCTTTACGTAAAAAACAGCGCAACACGCTGGAGCAGCTGTTTAAAACCCCCGTGCCGCAGGG
TATTAAATGGGCCGACATTGAATCGCTAATTAAAGCGTTAGGTGGGGAGATTAAAGAAGGACGCGGCTCGCGCTGTAAAT
TTTTGTTGAACCACAGCATTGCCAGCTTTCACAGGCCTCACCCTTCGCCGGATACTGACAAAGGCGCCGTGGAGAGCGTG
CGCGATTGGTTAATCACTATAGGAGTAAAACCATGA

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13305.02 Da        Isoelectric Point: 4.3472

>AT25375 WP_015703740.1 NC_015663:c1181731-1181372 [Klebsiella aerogenes KCTC 2190]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQQEGEISLQEYLADCREAGIEPYAQPEKLKT
FTLRYPESFGERLSSAAAEEQVSVNTWILETLNERLKQA

Download         Length: 360 bp

>AT25375 NC_015663:c1181731-1181372 [Klebsiella aerogenes KCTC 2190]
ATGATCAAACCTAAAACGCCAAATTCAATGGAGATTGCCGGGCAGCCTGCTGTTATCAACTACGTGCCTGAACTCAATGC
ATTCCGCGGTAAGTTCCTGGGATTATCAGGATATTGCGATTTTGTTTCCGATAGCATTCAAGGGTTACAACAGGAGGGCG
AGATATCATTACAGGAATATCTTGCTGATTGTCGTGAAGCGGGCATCGAGCCTTATGCTCAGCCGGAAAAGCTGAAAACC
TTCACATTGCGCTATCCTGAATCATTTGGTGAGCGTCTTAGCTCCGCCGCTGCAGAGGAGCAGGTTTCCGTAAATACCTG
GATCCTTGAGACGCTCAATGAACGTCTCAAACAGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FL31

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FNK6

References