Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2270386..2271004 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NUI00_RS11060 Protein ID WP_001291435.1
Coordinates 2270786..2271004 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NUI00_RS11055 Protein ID WP_000344800.1
Coordinates 2270386..2270760 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS11045 (2265475) 2265475..2266668 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NUI00_RS11050 (2266691) 2266691..2269840 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
NUI00_RS11055 (2270386) 2270386..2270760 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NUI00_RS11060 (2270786) 2270786..2271004 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NUI00_RS11065 (2271176) 2271176..2271727 + 552 WP_000102559.1 maltose O-acetyltransferase -
NUI00_RS11070 (2271843) 2271843..2272313 + 471 WP_000136192.1 YlaC family protein -
NUI00_RS11075 (2272477) 2272477..2274027 + 1551 WP_001389864.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NUI00_RS11080 (2274069) 2274069..2274422 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NUI00_RS11090 (2274801) 2274801..2275112 + 312 WP_000409911.1 MGMT family protein -
NUI00_RS11095 (2275143) 2275143..2275715 - 573 WP_257739432.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T253746 WP_001291435.1 NZ_CP102488:2270786-2271004 [Escherichia coli O15:H18]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT253746 WP_000344800.1 NZ_CP102488:2270386-2270760 [Escherichia coli O15:H18]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References