Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 1810553..1811258 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag NUI00_RS08870 Protein ID WP_000539521.1
Coordinates 1810553..1810939 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUI00_RS08875 Protein ID WP_001280945.1
Coordinates 1810929..1811258 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS08850 (1806557) 1806557..1807183 + 627 WP_001295292.1 glutathione S-transferase GstB -
NUI00_RS08855 (1807180) 1807180..1808295 - 1116 Protein_1740 aldose sugar dehydrogenase YliI -
NUI00_RS08860 (1808406) 1808406..1808789 - 384 WP_000497137.1 biofilm formation regulator BssR -
NUI00_RS08865 (1809002) 1809002..1810327 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
NUI00_RS08870 (1810553) 1810553..1810939 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUI00_RS08875 (1810929) 1810929..1811258 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
NUI00_RS08880 (1811328) 1811328..1812656 - 1329 WP_000086879.1 GGDEF domain-containing protein -
NUI00_RS08885 (1812664) 1812664..1815012 - 2349 WP_001322378.1 EAL domain-containing protein -
NUI00_RS08890 (1815190) 1815190..1816101 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T253745 WP_000539521.1 NZ_CP102488:1810553-1810939 [Escherichia coli O15:H18]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT253745 WP_001280945.1 NZ_CP102488:1810929-1811258 [Escherichia coli O15:H18]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References