253744

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1563349..1564133 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag NUI00_RS07700 Protein ID WP_000613626.1
Coordinates 1563639..1564133 (+) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag NUI00_RS07695 Protein ID WP_001110447.1
Coordinates 1563349..1563642 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS07685 (1558499) 1558499..1559458 - 960 WP_000846342.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -
NUI00_RS07690 (1560031) 1560031..1563216 + 3186 WP_000827427.1 ribonuclease E -
NUI00_RS07695 (1563349) 1563349..1563642 + 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
NUI00_RS07700 (1563639) 1563639..1564133 + 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
NUI00_RS07705 (1564228) 1564228..1565181 - 954 WP_001212768.1 flagellar hook-associated protein FlgL -
NUI00_RS07710 (1565193) 1565193..1566836 - 1644 WP_000096524.1 flagellar hook-associated protein FlgK -
NUI00_RS07715 (1566902) 1566902..1567843 - 942 WP_001309406.1 flagellar assembly peptidoglycan hydrolase FlgJ -
NUI00_RS07720 (1567843) 1567843..1568940 - 1098 WP_000589320.1 flagellar basal body P-ring protein FlgI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T253744 WP_000613626.1 NZ_CP102488:1563639-1564133 [Escherichia coli O15:H18]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT253744 WP_001110447.1 NZ_CP102488:1563349-1563642 [Escherichia coli O15:H18]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References