Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1069682..1071270 Replicon chromosome
Accession NZ_CP102488
Organism Escherichia coli O15:H18 strain ST69

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NUI00_RS05110 Protein ID WP_001546825.1
Coordinates 1069948..1071270 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag NUI00_RS05105 Protein ID WP_001296726.1
Coordinates 1069682..1069948 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUI00_RS05105 (1069682) 1069682..1069948 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NUI00_RS05110 (1069948) 1069948..1071270 + 1323 WP_001546825.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
NUI00_RS05115 (1071668) 1071668..1072567 - 900 WP_001057776.1 LysR family transcriptional regulator -
NUI00_RS05120 (1072707) 1072707..1073015 + 309 WP_001221046.1 hypothetical protein -
NUI00_RS05125 (1073024) 1073024..1073713 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
NUI00_RS05130 (1073787) 1073787..1074734 + 948 WP_000854796.1 aldo/keto reductase -
NUI00_RS05135 (1074837) 1074837..1074992 + 156 WP_001322415.1 hypothetical protein -
NUI00_RS05140 (1074952) 1074952..1075371 + 420 WP_001322416.1 amidohydrolase family protein -
NUI00_RS05145 (1075361) 1075361..1075513 + 153 WP_001322417.1 amidohydrolase family protein -
NUI00_RS05150 (1075664) 1075664..1076236 + 573 WP_000789913.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49331.00 Da        Isoelectric Point: 8.1369

>T253741 WP_001546825.1 NZ_CP102488:1069948-1071270 [Escherichia coli O15:H18]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHCRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT253741 WP_001296726.1 NZ_CP102488:1069682-1069948 [Escherichia coli O15:H18]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References