Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 593232..593889 Replicon chromosome
Accession NC_015663
Organism Enterobacter aerogenes KCTC 2190

Toxin (Protein)


Gene name cptA Uniprot ID A0A0H3FM52
Locus tag EAE_RS02890 Protein ID WP_015369792.1
Coordinates 593232..593642 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3FJK6
Locus tag EAE_RS02895 Protein ID WP_015369791.1
Coordinates 593623..593889 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EAE_RS02870 589231..590964 - 1734 WP_015369796.1 single-stranded-DNA-specific exonuclease RecJ -
EAE_RS02875 590970..591683 - 714 WP_015369795.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
EAE_RS02880 591706..592602 - 897 WP_015703420.1 site-specific tyrosine recombinase XerD -
EAE_RS02885 592703..593224 + 522 WP_015369793.1 flavodoxin FldB -
EAE_RS02890 593232..593642 - 411 WP_015369792.1 protein YgfX Toxin
EAE_RS02895 593623..593889 - 267 WP_015369791.1 FAD assembly factor SdhE Antitoxin
EAE_RS02900 594113..595096 + 984 WP_015703421.1 tRNA-modifying protein YgfZ -
EAE_RS02905 595195..595854 - 660 WP_008806429.1 hemolysin III family protein -
EAE_RS02910 596019..596330 - 312 WP_015703422.1 N(4)-acetylcytidine aminohydrolase -
EAE_RS02915 596381..597115 + 735 WP_015703423.1 MurR/RpiR family transcriptional regulator -
EAE_RS02920 597229..598662 + 1434 WP_015369787.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15887.69 Da        Isoelectric Point: 10.0200

>T25374 WP_015369792.1 NC_015663:c593642-593232 [Klebsiella aerogenes KCTC 2190]
VVLWQSDLRISWRSQWFSLLLHGVVAAIVLLMPWPLSYTPIWLLLLSLVVFDCVRSQRRIHACQGEIKLLIDSRLRWQKT
EWDIVGTPWVISSGMLLRLKHAETGRSQHLWVAADSMDAGEWRDLRRLVLQKPAHD

Download         Length: 411 bp

>T25374 NC_015663:c593642-593232 [Klebsiella aerogenes KCTC 2190]
GTGGTCCTGTGGCAATCTGATTTACGTATTTCCTGGCGTTCGCAGTGGTTCTCGCTGCTGCTGCACGGGGTGGTGGCGGC
GATAGTGCTGCTCATGCCCTGGCCGTTAAGCTACACCCCGATTTGGCTCCTGTTGCTATCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCACGCCTGCCAGGGAGAAATTAAGCTGTTGATCGATTCCCGTTTACGGTGGCAAAAAACG
GAATGGGATATCGTCGGGACGCCATGGGTTATCAGCAGCGGGATGCTGCTGCGCCTGAAGCATGCGGAAACCGGCCGTAG
CCAGCATTTGTGGGTGGCGGCGGATAGTATGGATGCGGGAGAATGGCGGGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCACGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10579.09 Da        Isoelectric Point: 5.6963

>AT25374 WP_015369791.1 NC_015663:c593889-593623 [Klebsiella aerogenes KCTC 2190]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGKPADAQLQRMINLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT25374 NC_015663:c593889-593623 [Klebsiella aerogenes KCTC 2190]
ATGGACATTAACAACAAAGCTCGCATCCACTGGGCATGCCGCCGCGGTATGCGCGAACTCGATATCTCCATCATGCCGTT
TTTCGAGTATGAGTACGACACGCTCAGCGATGACGACAAGCGCCTGTTCATCCGTTTGCTGGAGAACGATGATCCGGATC
TGTTTAACTGGCTGATGAATCACGGCAAGCCGGCAGATGCGCAACTTCAACGGATGATTAATTTAATCCAGACTCGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FM52

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FJK6

References