Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 243759..244353 Replicon chromosome
Accession NZ_CP102485
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name PumA Uniprot ID A0A228JB64
Locus tag NTJ56_RS39510 Protein ID WP_027811055.1
Coordinates 244060..244353 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A228JAU5
Locus tag NTJ56_RS39505 Protein ID WP_027811056.1
Coordinates 243759..244058 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS39485 (NTJ56_39485) 239057..241123 - 2067 WP_027811059.1 type IV secretion system DNA-binding domain-containing protein -
NTJ56_RS39490 (NTJ56_39490) 241116..241517 - 402 WP_027811058.1 hypothetical protein -
NTJ56_RS39495 (NTJ56_39495) 242534..243037 + 504 WP_143277545.1 hypothetical protein -
NTJ56_RS39500 (NTJ56_39500) 243285..243596 + 312 WP_027811057.1 hypothetical protein -
NTJ56_RS39505 (NTJ56_39505) 243759..244058 - 300 WP_027811056.1 putative addiction module antidote protein Antitoxin
NTJ56_RS39510 (NTJ56_39510) 244060..244353 - 294 WP_027811055.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NTJ56_RS39515 (NTJ56_39515) 244458..244601 - 144 WP_154233621.1 hypothetical protein -
NTJ56_RS39520 (NTJ56_39520) 244658..244879 - 222 WP_027811054.1 DUF3717 domain-containing protein -
NTJ56_RS39525 (NTJ56_39525) 244924..245475 - 552 WP_077186813.1 hypothetical protein -
NTJ56_RS39530 (NTJ56_39530) 245450..245716 - 267 WP_027811052.1 hypothetical protein -
NTJ56_RS39535 (NTJ56_39535) 246760..248889 - 2130 WP_039350079.1 ParB/RepB/Spo0J family partition protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(11-87)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10854.50 Da        Isoelectric Point: 10.6086

>T253733 WP_027811055.1 NZ_CP102485:c244353-244060 [Burkholderia contaminans]
MRIEQTDDFAKWLRGLRDHIARAQIAKRIQRLARGQYGDMKPVGAGVSEMRVHVGPGYRVYFVQRGSTLVVLLCGGDKST
QQRDIERAIALSAQLGD

Download         Length: 294 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10716.01 Da        Isoelectric Point: 4.6364

>AT253733 WP_027811056.1 NZ_CP102485:c244058-243759 [Burkholderia contaminans]
MGIKTTPFDAAEYLDTPEAQAEYLRISFETGDSADIQEAIGTVARARGMTQIARDAGVGRESLYKALDEHGNPEFATILR
VVRALGLTLTVTTPVHEHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A228JB64

Antitoxin

Source ID Structure
AlphaFold DB A0A228JAU5

References