Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2649356..2649976 Replicon chromosome
Accession NZ_CP102483
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NTJ56_RS30050 Protein ID WP_124471846.1
Coordinates 2649356..2649673 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag NTJ56_RS30055 Protein ID WP_039344756.1
Coordinates 2649677..2649976 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS30040 (NTJ56_30040) 2645900..2647333 - 1434 WP_071332978.1 aldehyde dehydrogenase family protein -
NTJ56_RS30045 (NTJ56_30045) 2647363..2649003 - 1641 WP_039344750.1 acetolactate synthase large subunit -
NTJ56_RS30050 (NTJ56_30050) 2649356..2649673 + 318 WP_124471846.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NTJ56_RS30055 (NTJ56_30055) 2649677..2649976 + 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
NTJ56_RS30060 (NTJ56_30060) 2650025..2651311 - 1287 WP_226222934.1 DUF445 domain-containing protein -
NTJ56_RS30065 (NTJ56_30065) 2651482..2652702 - 1221 WP_226222932.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NTJ56_RS30070 (NTJ56_30070) 2652692..2653018 - 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NTJ56_RS30075 (NTJ56_30075) 2653039..2653527 - 489 WP_069251004.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NTJ56_RS30080 (NTJ56_30080) 2653541..2654812 - 1272 WP_226222930.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11868.59 Da        Isoelectric Point: 9.5691

>T253731 WP_124471846.1 NZ_CP102483:2649356-2649673 [Burkholderia contaminans]
MPYSAPTFSIRTTDVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLAHLDME

Download         Length: 318 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT253731 WP_039344756.1 NZ_CP102483:2649677-2649976 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References