Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2310815..2311392 Replicon chromosome
Accession NZ_CP102483
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NTJ56_RS28550 Protein ID WP_226220494.1
Coordinates 2311027..2311392 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2HEK9
Locus tag NTJ56_RS28545 Protein ID WP_021160898.1
Coordinates 2310815..2311033 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS28520 (NTJ56_28520) 2306086..2306565 + 480 WP_226116504.1 GNAT family N-acetyltransferase -
NTJ56_RS28525 (NTJ56_28525) 2306656..2307921 - 1266 WP_226116502.1 Zn-dependent hydrolase -
NTJ56_RS28530 (NTJ56_28530) 2307914..2308438 - 525 WP_226220497.1 L-2-amino-thiazoline-4-carboxylic acid hydrolase -
NTJ56_RS28535 (NTJ56_28535) 2308483..2309649 - 1167 WP_226220496.1 branched-chain amino acid ABC transporter substrate-binding protein -
NTJ56_RS28540 (NTJ56_28540) 2309828..2310724 + 897 WP_226220495.1 LysR substrate-binding domain-containing protein -
NTJ56_RS28545 (NTJ56_28545) 2310815..2311033 + 219 WP_021160898.1 hypothetical protein Antitoxin
NTJ56_RS28550 (NTJ56_28550) 2311027..2311392 + 366 WP_226220494.1 type II toxin-antitoxin system VapC family toxin Toxin
NTJ56_RS28555 (NTJ56_28555) 2311732..2312295 + 564 WP_011547973.1 alkyl hydroperoxide reductase subunit C -
NTJ56_RS28560 (NTJ56_28560) 2312419..2314017 + 1599 WP_226116496.1 alkyl hydroperoxide reductase subunit F -
NTJ56_RS28565 (NTJ56_28565) 2314112..2314894 - 783 WP_226220493.1 extensin -
NTJ56_RS28570 (NTJ56_28570) 2315055..2315609 - 555 WP_226116492.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13421.47 Da        Isoelectric Point: 8.4389

>T253730 WP_226220494.1 NZ_CP102483:2311027-2311392 [Burkholderia contaminans]
MVKALFDTNILIDYLGGVESARAELGRYDYRAISTISWMEVLVGTSAQDEAPIRAWLSSFDVIALDSPVASRAVTIRKER
RIRLPDAIVWASAQVNGLLLVSRNTKDFPATEPGVRVPYKL

Download         Length: 366 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.51 Da        Isoelectric Point: 5.0604

>AT253730 WP_021160898.1 NZ_CP102483:2310815-2311033 [Burkholderia contaminans]
MSRILVDLSDGQLDELAVIVETQHRPRAAIIRDAIDAYIALHKHRLADDVFGLWKDRKVDGLTYQEELRSEW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U2HEK9

References