25373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3634912..3635548 Replicon chromosome
Accession NC_015660
Organism Geobacillus thermoglucosidasius C56-YS93

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag GEOTH_RS18265 Protein ID WP_003253417.1
Coordinates 3634912..3635262 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A178U3Z0
Locus tag GEOTH_RS18270 Protein ID WP_003253419.1
Coordinates 3635267..3635548 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GEOTH_RS18255 3631852..3632319 - 468 WP_003253403.1 SprT family protein -
GEOTH_RS21040 3632407..3632520 + 114 WP_013401775.1 cortex morphogenetic protein CmpA -
GEOTH_RS18260 3632515..3634701 - 2187 WP_013877616.1 RNA-binding transcriptional accessory protein -
GEOTH_RS18265 3634912..3635262 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
GEOTH_RS18270 3635267..3635548 - 282 WP_003253419.1 hypothetical protein Antitoxin
GEOTH_RS18275 3635671..3636825 - 1155 WP_003253421.1 alanine racemase -
GEOTH_RS18280 3637002..3638015 - 1014 WP_041270136.1 outer membrane lipoprotein-sorting protein -
GEOTH_RS18285 3638097..3638459 - 363 WP_013877619.1 holo-ACP synthase -
GEOTH_RS18290 3638522..3639136 + 615 WP_013401779.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T25373 WP_003253417.1 NC_015660:c3635262-3634912 [Parageobacillus thermoglucosidasius C56-YS93]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T25373 NC_015660:c3635262-3634912 [Parageobacillus thermoglucosidasius C56-YS93]
TTGATTGTTAAGCGTGGCGACGTTTATTTTGCGGACCTTTCCCCGGTAGTTGGCTCGGAACAAGGAGGCGTTCGTCCGGT
ATTAGTCATTCAAAATGACATTGGAAATCGGTTTAGTCCGACGGTGATTGTGGCGGCGATAACAGCGCAAATCCAAAAAG
CAAAGCTGCCGACACATGTTGAAATTGACGCGAAGCGTTACGGGTTTGAGCGGGATTCTGTTATTCTGCTAGAGCAAATT
CGGACGATTGATAAGCAGCGGCTGACAGACAAAATTACTCACTTGGACGATGAAATGATGGATAAGGTGGATGAAGCGCT
GCAAATTAGTTTAGGACTCATAGATTTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10631.16 Da        Isoelectric Point: 7.0142

>AT25373 WP_003253419.1 NC_015660:c3635548-3635267 [Parageobacillus thermoglucosidasius C56-YS93]
VSESSATTEIVVRLPQALVTELDVLVKQENGNRNDLIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFLAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT25373 NC_015660:c3635548-3635267 [Parageobacillus thermoglucosidasius C56-YS93]
GTGTCGGAATCTAGCGCAACAACGGAAATCGTCGTTCGTTTACCTCAAGCACTAGTAACGGAATTGGATGTGCTTGTTAA
ACAAGAGAACGGCAACCGTAATGATCTCATTTATCAAGCAACTAAAATGTACATTCGCGAGCGAAAAAAACGGCAAATCC
GCGAGGCGATGAGACGCGGTTATATGGAAATGGCGAAAATCAATTTATCCATTGCTTCAGAGGCGTTTCTTGCAGAATAT
GAAGCCGACCACACCGTTGAGCGTTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A178U3Z0

References