Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1789069..1789708 Replicon chromosome
Accession NZ_CP102483
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NTJ56_RS26285 Protein ID WP_226220940.1
Coordinates 1789292..1789708 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A1X1PQC0
Locus tag NTJ56_RS26280 Protein ID WP_039351245.1
Coordinates 1789069..1789305 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS26265 (NTJ56_26265) 1784828..1786408 + 1581 WP_226220718.1 FadD3 family acyl-CoA ligase -
NTJ56_RS26270 (NTJ56_26270) 1786477..1787220 + 744 WP_226220717.1 SDR family oxidoreductase -
NTJ56_RS26275 (NTJ56_26275) 1788012..1788671 + 660 WP_226122407.1 hypothetical protein -
NTJ56_RS26280 (NTJ56_26280) 1789069..1789305 + 237 WP_039351245.1 DNA-binding protein Antitoxin
NTJ56_RS26285 (NTJ56_26285) 1789292..1789708 + 417 WP_226220940.1 type II toxin-antitoxin system VapC family toxin Toxin
NTJ56_RS26290 (NTJ56_26290) 1790064..1791509 - 1446 WP_226220716.1 GSCFA domain-containing protein -
NTJ56_RS26295 (NTJ56_26295) 1792055..1792951 + 897 WP_226220715.1 VOC family protein -
NTJ56_RS26300 (NTJ56_26300) 1792961..1793854 + 894 WP_226220714.1 CoA-transferase -
NTJ56_RS26305 (NTJ56_26305) 1793865..1794662 + 798 WP_226220713.1 ketoacid CoA transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15342.67 Da        Isoelectric Point: 8.5855

>T253728 WP_226220940.1 NZ_CP102483:1789292-1789708 [Burkholderia contaminans]
VYLIDTNIISEIRRGKRTNRGVRAFFRQVAADASPLYLSVVTVAELRRGVDLIRHRGDHAQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVADFARTGVKLLNPFD

Download         Length: 417 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8598.61 Da        Isoelectric Point: 5.0477

>AT253728 WP_039351245.1 NZ_CP102483:1789069-1789305 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1PQC0

References