Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1535661..1537411 Replicon chromosome
Accession NZ_CP102483
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag NTJ56_RS25195 Protein ID WP_226220833.1
Coordinates 1535661..1536557 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag NTJ56_RS25200 Protein ID WP_226120176.1
Coordinates 1536554..1537411 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS25165 (NTJ56_25165) 1531024..1532109 - 1086 WP_226120182.1 porin -
NTJ56_RS25170 (NTJ56_25170) 1532555..1532872 + 318 WP_011354710.1 non-heme iron oxygenase ferredoxin subunit -
NTJ56_RS25175 (NTJ56_25175) 1532874..1533185 + 312 WP_039344088.1 hypothetical protein -
NTJ56_RS25180 (NTJ56_25180) 1533238..1534314 + 1077 WP_039344090.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NTJ56_RS25185 (NTJ56_25185) 1534307..1535077 + 771 WP_226120180.1 SDR family oxidoreductase -
NTJ56_RS25190 (NTJ56_25190) 1535115..1535642 + 528 WP_069260265.1 cupin domain-containing protein -
NTJ56_RS25195 (NTJ56_25195) 1535661..1536557 + 897 WP_226220833.1 alpha/beta fold hydrolase Toxin
NTJ56_RS25200 (NTJ56_25200) 1536554..1537411 + 858 WP_226120176.1 IclR family transcriptional regulator Antitoxin
NTJ56_RS25205 (NTJ56_25205) 1537408..1538205 + 798 WP_226220832.1 SDR family oxidoreductase -
NTJ56_RS25210 (NTJ56_25210) 1538198..1539865 + 1668 WP_226220831.1 thiamine pyrophosphate-binding protein -
NTJ56_RS25215 (NTJ56_25215) 1539858..1540685 + 828 WP_226220830.1 aspartate dehydrogenase -
NTJ56_RS25220 (NTJ56_25220) 1540758..1542248 + 1491 WP_226220829.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30715.02 Da        Isoelectric Point: 8.3561

>T253727 WP_226220833.1 NZ_CP102483:1535661-1536557 [Burkholderia contaminans]
MSVIDKRERDRTAAFAGLLGQFPERRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGGAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDQQRGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31348.84 Da        Isoelectric Point: 6.5061

>AT253727 WP_226120176.1 NZ_CP102483:1536554-1537411 [Burkholderia contaminans]
MNEPLQQPESENGKAEAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References