Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1367079..1367734 Replicon chromosome
Accession NZ_CP102483
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name vapC Uniprot ID U2HGC0
Locus tag NTJ56_RS24425 Protein ID WP_021158162.1
Coordinates 1367315..1367734 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U2HMP5
Locus tag NTJ56_RS24420 Protein ID WP_021158161.1
Coordinates 1367079..1367318 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS24400 (NTJ56_24400) 1362441..1362856 - 416 Protein_1231 IS5 family transposase -
NTJ56_RS24405 (NTJ56_24405) 1363062..1363745 - 684 WP_226118815.1 Fe2+-dependent dioxygenase -
NTJ56_RS24410 (NTJ56_24410) 1363742..1364521 - 780 WP_226220903.1 tetratricopeptide repeat protein -
NTJ56_RS24415 (NTJ56_24415) 1364525..1366768 - 2244 WP_226118813.1 TonB-dependent siderophore receptor -
NTJ56_RS24420 (NTJ56_24420) 1367079..1367318 + 240 WP_021158161.1 antitoxin VapB Antitoxin
NTJ56_RS24425 (NTJ56_24425) 1367315..1367734 + 420 WP_021158162.1 type II toxin-antitoxin system VapC family toxin Toxin
NTJ56_RS24430 (NTJ56_24430) 1367870..1369165 - 1296 WP_226220902.1 aspartate carbamoyltransferase -
NTJ56_RS24435 (NTJ56_24435) 1369399..1369533 + 135 WP_021158165.1 entericidin A/B family lipoprotein -
NTJ56_RS24440 (NTJ56_24440) 1369633..1370181 - 549 WP_226118811.1 permease -
NTJ56_RS24445 (NTJ56_24445) 1370390..1371358 - 969 WP_226220901.1 DMT family transporter -
NTJ56_RS24450 (NTJ56_24450) 1371584..1372378 - 795 WP_226220900.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1359376..1367734 8358


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15212.57 Da        Isoelectric Point: 5.9052

>T253726 WP_021158162.1 NZ_CP102483:1367315-1367734 [Burkholderia contaminans]
MILVDTNVISEPLRREPNAAVIEWLDAQNVETLFLAAISLAEIRLGVAVLPEGRRREWLHQSIEQRVLPLFRGRILPFDD
AASKAYASLRARARAAGVAIAPSDGFIAGTAEANGLIVATRDVTPFEAMGIRVIDPWAR

Download         Length: 420 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8629.79 Da        Isoelectric Point: 5.6643

>AT253726 WP_021158161.1 NZ_CP102483:1367079-1367318 [Burkholderia contaminans]
MPVITVRNLSDEVHRALRIRAAQHGRSTEAEVRDILEQAVLPGGRLKLGTMLAAIGQEAGGFDFDAQRDKTPADPMSFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2HGC0

Antitoxin

Source ID Structure
AlphaFold DB U2HMP5

References