Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1968384..1969057 Replicon chromosome
Accession NZ_CP102482
Organism Burkholderia contaminans strain DM32

Toxin (Protein)


Gene name vagD Uniprot ID U2G353
Locus tag NTJ56_RS09305 Protein ID WP_021160096.1
Coordinates 1968641..1969057 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID U2FLJ7
Locus tag NTJ56_RS09300 Protein ID WP_021160097.1
Coordinates 1968384..1968644 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NTJ56_RS09285 (NTJ56_09285) 1963931..1966192 + 2262 WP_226224735.1 TonB-dependent siderophore receptor -
NTJ56_RS09290 (NTJ56_09290) 1966279..1967118 + 840 WP_226224738.1 formyltransferase family protein -
NTJ56_RS09295 (NTJ56_09295) 1967118..1968134 + 1017 WP_226121616.1 GNAT family N-acetyltransferase -
NTJ56_RS09300 (NTJ56_09300) 1968384..1968644 + 261 WP_021160097.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NTJ56_RS09305 (NTJ56_09305) 1968641..1969057 + 417 WP_021160096.1 PIN domain-containing protein Toxin
NTJ56_RS09310 (NTJ56_09310) 1969106..1970011 - 906 WP_226224741.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NTJ56_RS09315 (NTJ56_09315) 1969980..1971053 - 1074 WP_226224743.1 type IV toxin-antitoxin system AbiEi family antitoxin -
NTJ56_RS09320 (NTJ56_09320) 1971395..1972558 + 1164 WP_226224745.1 M20 aminoacylase family protein -
NTJ56_RS09325 (NTJ56_09325) 1972801..1973340 + 540 WP_048020589.1 outer membrane protein assembly factor BamE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14566.75 Da        Isoelectric Point: 7.8895

>T253722 WP_021160096.1 NZ_CP102482:1968641-1969057 [Burkholderia contaminans]
VTTLYMLDTNICSFIMRERPPVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRADLAARGMPIGANDASIAGHAIAAGAVLVTNNGREFGRVAGLSLEDWAA

Download         Length: 417 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9546.80 Da        Isoelectric Point: 4.6151

>AT253722 WP_021160097.1 NZ_CP102482:1968384-1968644 [Burkholderia contaminans]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPLADADFLAERPAVIESGRFDLSGGAA
PTESGQ

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U2G353

Antitoxin

Source ID Structure
AlphaFold DB U2FLJ7

References