Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3920305..3920924 Replicon chromosome
Accession NZ_CP102479
Organism Klebsiella aerogenes strain TS2020

Toxin (Protein)


Gene name Hha Uniprot ID A0A0H3FXE2
Locus tag NUT96_RS18680 Protein ID WP_015367918.1
Coordinates 3920706..3920924 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0H3FPM3
Locus tag NUT96_RS18675 Protein ID WP_015367917.1
Coordinates 3920305..3920679 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUT96_RS18665 (3915463) 3915463..3916662 + 1200 WP_020079451.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NUT96_RS18670 (3916685) 3916685..3919831 + 3147 WP_015367916.1 multidrug efflux RND transporter permease subunit AcrB -
NUT96_RS18675 (3920305) 3920305..3920679 + 375 WP_015367917.1 Hha toxicity modulator TomB Antitoxin
NUT96_RS18680 (3920706) 3920706..3920924 + 219 WP_015367918.1 HHA domain-containing protein Toxin
NUT96_RS18685 (3921056) 3921056..3921619 + 564 WP_020079452.1 maltose O-acetyltransferase -
NUT96_RS18690 (3921745) 3921745..3922209 + 465 WP_015367920.1 YlaC family protein -
NUT96_RS18695 (3922184) 3922184..3923638 - 1455 WP_045361851.1 PLP-dependent aminotransferase family protein -
NUT96_RS18700 (3923741) 3923741..3924451 + 711 WP_015704607.1 GNAT family protein -
NUT96_RS18705 (3924448) 3924448..3924588 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
NUT96_RS18710 (3924591) 3924591..3924851 - 261 WP_015367923.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8569.96 Da        Isoelectric Point: 9.4828

>T253718 WP_015367918.1 NZ_CP102479:3920706-3920924 [Klebsiella aerogenes]
MSGKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14464.21 Da        Isoelectric Point: 4.9045

>AT253718 WP_015367917.1 NZ_CP102479:3920305-3920679 [Klebsiella aerogenes]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNRGWVNDPTSAVNLQLNELIEHIATYALNYKIKYAEDNKLISQLDEYL
DDTFMLFSSYGINTSDLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3FXE2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3FPM3

References