Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-VagC
Location 6391..7040 Replicon plasmid unnamed1
Accession NZ_CP102478
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ27_RS36500 Protein ID WP_006482112.1
Coordinates 6391..6801 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EQM9
Locus tag NUJ27_RS36505 Protein ID WP_006482117.1
Coordinates 6798..7040 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS36480 (NUJ27_36480) 1917..2432 - 516 WP_227743147.1 plasmid pRiA4b ORF-3 family protein -
NUJ27_RS36485 (NUJ27_36485) 2976..4781 - 1806 Protein_3 site-specific integrase -
NUJ27_RS36490 (NUJ27_36490) 5255..5572 - 318 WP_006493600.1 hypothetical protein -
NUJ27_RS36495 (NUJ27_36495) 5732..6091 - 360 WP_006493602.1 hypothetical protein -
NUJ27_RS36500 (NUJ27_36500) 6391..6801 - 411 WP_006482112.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ27_RS36505 (NUJ27_36505) 6798..7040 - 243 WP_006482117.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NUJ27_RS36510 (NUJ27_36510) 7161..8129 - 969 WP_077176027.1 non-homologous end-joining DNA ligase -
NUJ27_RS36515 (NUJ27_36515) 8646..9317 + 672 WP_006482119.1 AAA family ATPase -
NUJ27_RS36520 (NUJ27_36520) 9317..10282 + 966 WP_006482114.1 ParB/RepB/Spo0J family partition protein -
NUJ27_RS36525 (NUJ27_36525) 11008..11865 + 858 WP_006482109.1 plasmid replication initiator TrfA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..94494 94494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-125)

Antitoxin

SpoVT-AbrB domain

(12-49)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14783.04 Da        Isoelectric Point: 5.1526

>T253709 WP_006482112.1 NZ_CP102478:c6801-6391 [Burkholderia cenocepacia]
MTLYLLDTNILSNVIRDPRGACATRIGETPPEQVCTSIVVAAELRFGVWKRGSSTLAQRVEQLLASLTVLPLQPDADRCY
GRLRAELEKQGQLIGANDMLIAAHALAVDAVLVTDNTAEFTRVAGLPVENWLRPAT

Download         Length: 411 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9285.51 Da        Isoelectric Point: 4.5317

>AT253709 WP_006482117.1 NZ_CP102478:c7040-6798 [Burkholderia cenocepacia]
MPTHDTRHARLFRNGRSQAVRIPREFELPVSEVTIQREGRRLIIEPVEAAPLRELFAQWAPLDETFPDIEDLPAEPVDIE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB B4EQM9

References