Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 2590655..2591263 Replicon chromosome
Accession NZ_CP102476
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NUJ27_RS29460 Protein ID WP_006490978.1
Coordinates 2590655..2590960 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NUJ27_RS29465 Protein ID WP_006490972.1
Coordinates 2590964..2591263 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS29450 (NUJ27_29450) 2587164..2588597 - 1434 WP_006490987.1 aldehyde dehydrogenase family protein -
NUJ27_RS29455 (NUJ27_29455) 2588626..2590266 - 1641 WP_006490980.1 acetolactate synthase large subunit -
NUJ27_RS29460 (NUJ27_29460) 2590655..2590960 + 306 WP_006490978.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NUJ27_RS29465 (NUJ27_29465) 2590964..2591263 + 300 WP_006490972.1 putative addiction module antidote protein Antitoxin
NUJ27_RS29470 (NUJ27_29470) 2591312..2592598 - 1287 WP_006490986.1 DUF445 domain-containing protein -
NUJ27_RS29475 (NUJ27_29475) 2592695..2593915 - 1221 WP_006490971.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
NUJ27_RS29480 (NUJ27_29480) 2593905..2594231 - 327 WP_006490973.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
NUJ27_RS29485 (NUJ27_29485) 2594267..2594743 - 477 WP_006490977.1 anthranilate 1,2-dioxygenase small subunit AndAd -
NUJ27_RS29490 (NUJ27_29490) 2594759..2596030 - 1272 WP_006490988.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-96)

Antitoxin

Uncharacterized protein HI1420

(4-96)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11270.88 Da        Isoelectric Point: 7.2764

>T253708 WP_006490978.1 NZ_CP102476:2590655-2590960 [Burkholderia cenocepacia]
MPYSPPAFSIRTTDVFDAWFAGLPDRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYDVRRGTIWVILLCGGD
KSAQQADIRAAHAMLAHLDME

Download         Length: 306 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10608.04 Da        Isoelectric Point: 6.4771

>AT253708 WP_006490972.1 NZ_CP102476:2590964-2591263 [Burkholderia cenocepacia]
MDKIKTRPWDSAEHLKTEDDMADYFDACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAAA

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References