Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2185441..2186087 Replicon chromosome
Accession NZ_CP102476
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name vapC Uniprot ID B4EGU9
Locus tag NUJ27_RS27560 Protein ID WP_006491144.1
Coordinates 2185441..2185848 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B4EGU8
Locus tag NUJ27_RS27565 Protein ID WP_006491146.1
Coordinates 2185845..2186087 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS27540 (NUJ27_27540) 2181335..2181916 - 582 WP_006486232.1 hypothetical protein -
NUJ27_RS27545 2181913..2182641 - 729 WP_034178465.1 methyl-accepting chemotaxis protein -
NUJ27_RS27550 (NUJ27_27550) 2182664..2185039 - 2376 WP_006491138.1 MCP four helix bundle domain-containing protein -
NUJ27_RS27555 (NUJ27_27555) 2185097..2185324 + 228 WP_006491154.1 hypothetical protein -
NUJ27_RS27560 (NUJ27_27560) 2185441..2185848 - 408 WP_006491144.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ27_RS27565 (NUJ27_27565) 2185845..2186087 - 243 WP_006491146.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NUJ27_RS27570 (NUJ27_27570) 2186346..2187029 + 684 WP_006491145.1 phospholipase -
NUJ27_RS27575 (NUJ27_27575) 2187103..2188608 - 1506 WP_006491141.1 amino acid permease -
NUJ27_RS27580 (NUJ27_27580) 2188686..2190092 - 1407 WP_006491136.1 aspartate ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-49)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14822.93 Da        Isoelectric Point: 6.2165

>T253707 WP_006491144.1 NZ_CP102476:c2185848-2185441 [Burkholderia cenocepacia]
MKFLLDTNAVIAILKGEPAILARLHAWHPADFGIPAIVAHALYYGAYKSQRAAANVARVEALQFEVVSFDTEDAQHAGEI
RAHLIAAGTPIGPYDALIAGQARARQLVLVTHNVREFERVPRLQFEDWLAEPSAD

Download         Length: 408 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.02 Da        Isoelectric Point: 5.0197

>AT253707 WP_006491146.1 NZ_CP102476:c2186087-2185845 [Burkholderia cenocepacia]
MDTAKLFKHGGSQAVRLPKDFRFDTAEVRIRRHGAAVILEPMPQDWAWLAPLIGPVDADFEAAATTQPSAQERSGLDVFE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EGU9

Antitoxin

Source ID Structure
AlphaFold DB B4EGU8

References