Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1668259..1668898 Replicon chromosome
Accession NZ_CP102476
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NUJ27_RS25280 Protein ID WP_006481544.1
Coordinates 1668482..1668898 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A364H554
Locus tag NUJ27_RS25275 Protein ID WP_006481537.1
Coordinates 1668259..1668495 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS25260 (NUJ27_25260) 1664430..1665203 + 774 WP_006481545.1 SDR family oxidoreductase -
NUJ27_RS25265 (NUJ27_25265) 1665852..1666529 + 678 WP_077176171.1 hypothetical protein -
NUJ27_RS25270 (NUJ27_25270) 1666540..1667766 - 1227 WP_006481535.1 acyltransferase -
NUJ27_RS25275 (NUJ27_25275) 1668259..1668495 + 237 WP_006481537.1 DNA-binding protein Antitoxin
NUJ27_RS25280 (NUJ27_25280) 1668482..1668898 + 417 WP_006481544.1 type II toxin-antitoxin system VapC family toxin Toxin
NUJ27_RS25285 (NUJ27_25285) 1669158..1670054 + 897 WP_006481531.1 VOC family protein -
NUJ27_RS25290 (NUJ27_25290) 1670064..1670957 + 894 WP_006481548.1 CoA-transferase -
NUJ27_RS25295 (NUJ27_25295) 1670968..1671765 + 798 WP_006481539.1 hypothetical protein -
NUJ27_RS25300 (NUJ27_25300) 1671774..1672694 + 921 WP_006481536.1 enoyl-CoA hydratase -
NUJ27_RS25305 (NUJ27_25305) 1672691..1673791 + 1101 WP_006481534.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15402.64 Da        Isoelectric Point: 6.8818

>T253706 WP_006481544.1 NZ_CP102476:1668482-1668898 [Burkholderia cenocepacia]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWLTMILSGYAPNI
LPVDVETGQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFE

Download         Length: 417 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8710.78 Da        Isoelectric Point: 5.0916

>AT253706 WP_006481537.1 NZ_CP102476:1668259-1668495 [Burkholderia cenocepacia]
MANLLVRNVDDTLVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A364H554

References