Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1421182..1422973 Replicon chromosome
Accession NZ_CP102476
Organism Burkholderia cenocepacia strain NML110041

Toxin (Protein)


Gene name doc Uniprot ID B4EMB1
Locus tag NUJ27_RS24195 Protein ID WP_006493862.1
Coordinates 1421182..1422078 (+) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B4EMB0
Locus tag NUJ27_RS24200 Protein ID WP_006487201.1
Coordinates 1422116..1422973 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUJ27_RS24165 (NUJ27_24165) 1416559..1417638 - 1080 WP_006489902.1 porin -
NUJ27_RS24170 (NUJ27_24170) 1418083..1418400 + 318 WP_006489883.1 non-heme iron oxygenase ferredoxin subunit -
NUJ27_RS24175 (NUJ27_24175) 1418402..1418713 + 312 WP_006489911.1 hypothetical protein -
NUJ27_RS24180 (NUJ27_24180) 1418768..1419838 + 1071 WP_006489909.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
NUJ27_RS24185 (NUJ27_24185) 1419831..1420601 + 771 WP_263059946.1 SDR family oxidoreductase -
NUJ27_RS24190 (NUJ27_24190) 1420636..1421163 + 528 WP_006489904.1 cupin domain-containing protein -
NUJ27_RS24195 (NUJ27_24195) 1421182..1422078 + 897 WP_006493862.1 alpha/beta fold hydrolase Toxin
NUJ27_RS24200 (NUJ27_24200) 1422116..1422973 + 858 WP_006487201.1 IclR family transcriptional regulator Antitoxin
NUJ27_RS24205 (NUJ27_24205) 1422970..1423767 + 798 WP_006487171.1 SDR family oxidoreductase -
NUJ27_RS24210 (NUJ27_24210) 1423760..1425427 + 1668 WP_006487228.1 thiamine pyrophosphate-binding protein -
NUJ27_RS24215 (NUJ27_24215) 1425420..1426247 + 828 WP_006487191.1 aspartate dehydrogenase -
NUJ27_RS24220 (NUJ27_24220) 1426320..1427810 + 1491 WP_006487205.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-280)

Antitoxin

Transcription regulator IclR, C-terminal

(143-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30515.70 Da        Isoelectric Point: 7.3891

>T253705 WP_006493862.1 NZ_CP102476:1421182-1422078 [Burkholderia cenocepacia]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAAADYAAALNAWLEALGIERCVLVGHSLGAIIAGGLARVTPAQIAGLLLVSPAGGYGSAPAETR
EARRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAAYSALIDSFCRQCDTQWGLA

Download         Length: 897 bp

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31372.81 Da        Isoelectric Point: 5.9820

>AT253705 WP_006487201.1 NZ_CP102476:1422116-1422973 [Burkholderia cenocepacia]
MSEPLQQNESENAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGVLNRMTSATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLEALGLR

Download         Length: 858 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EMB1

Antitoxin

Source ID Structure
AlphaFold DB B4EMB0

References